A simple and rapid electrochemical strategy for non-invasive, sensitive and specific detection of cancerous cell
文献类型：期刊论文
| 作者 | Xu SL ; Liu JY ; Wang TS ; Li HL ; Miao YQ ; Liu YQ ; Wang J ; Wang EK |
| 刊名 | talanta
 |
| 出版日期 | 2013 |
| 卷号 | 104页码:122-127 |
| 关键词 | BIOCOMPATIBLE CONDUCTIVE ARCHITECTURE ESCHERICHIA-COLI O157-H7 FOLATE-BINDING PROTEIN IMPEDANCE SPECTROSCOPY SURFACE CARBOHYDRATE NANOPARTICLES BIOSENSOR IMMOBILIZATION GLYCOPROTEIN IMMUNOSENSOR |
| ISSN号 | 0039-9140 |
| 通讯作者 | liu yq |
| 中文摘要 | developing non-invasive, sensitive and specific sensing strategies for cancerous cell detection with simple and low cost instrumentations provide great advantages in cancer research and early diagnosis of diseases. in the present work, gold nanoparticles (au nps) functionalized with recognition components (folic acid) and signal indicator (ferrocene) was designed to fabricate electrochemical cytosensor. the au nps can not only accelerate electron transfer between signal indicator and the underlying electrode but also accumulate more ferrocene on the cytosensor surface to magnify signal for improving detection sensitivity. the surface-tethered folic acid plays a key role in specific binding folate receptor-riched hela cells on the cytosensor surface, resulting in corresponding current signal change measured by differential pulse voltammetry method. a wide detection range from 10 to 10(6) cells/ml with a detection limit as low as 10 cells/ml for cancerous cells was reached in the presence of a large amount of normal ones with fast differential pulse voltammetry measurement. detection of the captured cells can be finished within 1 min. the developed strategy provides a new way for operationally simple, rapid, sensitive and specific detection of cancerous cells. (c) 2012 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319310900019 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50084]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu SL,Liu JY,Wang TS,et al. A simple and rapid electrochemical strategy for non-invasive, sensitive and specific detection of cancerous cell[J]. talanta,2013,104:122-127. |
| APA | Xu SL.,Liu JY.,Wang TS.,Li HL.,Miao YQ.,...&Wang EK.(2013).A simple and rapid electrochemical strategy for non-invasive, sensitive and specific detection of cancerous cell.talanta,104,122-127. |
| MLA | Xu SL,et al."A simple and rapid electrochemical strategy for non-invasive, sensitive and specific detection of cancerous cell".talanta 104(2013):122-127. |
入库方式： OAI收割
来源：长春应用化学研究所
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