Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anticancer Drug Carrier and MRI Contrast Agent
文献类型：期刊论文
| 作者 | Kang XJ ; Yang DM ; Ma PA ; Dai YL ; Shang MM ; Geng DL ; Cheng ZY ; Lin J |
| 刊名 | langmuir
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:4页码:1286-1294 |
| 关键词 | SITU COPRECIPITATION SYNTHESIS MICROCRYSTALLINE PHOSPHORS LUMINESCENT PROPERTIES MAGNETIC-RESONANCE HYBRID PRECURSORS DELIVERY SPHERES NANOPARTICLES NANOCRYSTALS CONVERSION |
| ISSN号 | 0743-7463 |
| 通讯作者 | cheng zy |
| 中文摘要 | hollow and porous structured gdvo4:dy3+ spheres were fabricated via a facile self-sacrificing templated method. the large cavity allows them to be used as potential hosts for therapeutic drugs, and the porous feature of the shell allows guest molecules to easily pass through the void space and surrounding environment. the samples show strong yellow-green emission of dy3+ (485 nm, f-4(9/2) -> h-6(15/2); 575 nm, f-4(9/2) -> h-6(13/2)) under uv excitation. the emission intensity of gdvo4:dy3+ was weakened after encapsulation of anticancer drug (doxorubicin hydrochloride, dox) and gradually restored with the cumulative released time of dox. these hollow spheres were nontoxic to hela cells, while dox-loaded samples led to apparent cytotoxicity as a result of the sustained release of dox. icp measurement indicates that free toxic gd ions can hardly dissolate from the matrix. the endocytosis process of dox-loaded hollow spheres is observed using confocal laser scanning microscopy (clsm). furthermore, gdvo4:dy3+ hollow spheres can be used for t-1-weighted magnetic resonance (mr) imaging. these results implicate that the luminescent gdvo4:dy3+ spheres with hollow and porous structure are promising platforms for drug storage/release and mr imaging. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000314391300038 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50086]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kang XJ,Yang DM,Ma PA,et al. Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anticancer Drug Carrier and MRI Contrast Agent[J]. langmuir,2013,29(4):1286-1294. |
| APA | Kang XJ.,Yang DM.,Ma PA.,Dai YL.,Shang MM.,...&Lin J.(2013).Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anticancer Drug Carrier and MRI Contrast Agent.langmuir,29(4),1286-1294. |
| MLA | Kang XJ,et al."Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anticancer Drug Carrier and MRI Contrast Agent".langmuir 29.4(2013):1286-1294. |
入库方式： OAI收割
来源：长春应用化学研究所
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