A facile fabrication of upconversion luminescent and mesoporous core- shell structured beta-NaYF4:Yb3+, Er3+@mSiO(2) nanocomposite spheres for anti-cancer drug delivery and cell imaging
文献类型：期刊论文
| 作者 | Li CX ; Hou ZY ; Dai YL ; Yang DM ; Cheng ZY ; Ma PA ; Lin J |
| 刊名 | biomaterials science
 |
| 出版日期 | 2013 |
| 卷号 | 1期号:2页码:213-223 |
| 关键词 | DOPED NAYF4 NANOCRYSTALS SILICA NANOPARTICLES IN-VIVO FLUORESCENT NANOPARTICLES PHOTODYNAMIC THERAPY MAGNETIC-RESONANCE POROUS NAYF4/YB3+ UNIFORM BIOCOMPATIBILITY BIODISTRIBUTION |
| ISSN号 | 2047-4830 |
| 通讯作者 | li cx |
| 中文摘要 | upconversion luminescent beta-nayf4:yb3+, er3+ nanoparticles (ucnps) were encapsulated with uniform mesoporous silica shells, which were further modified with poly(ethylene glycol) (peg) and cancer-targeting ligand folic acid (fa), resulting in the formation of water-dispersible and biologically functionalized core-shell structured ucnps@msio(2) nanoparticles with an overall average size of around 80 nm. the obtained multifunctional nanocomposite spheres can be performed as an anti-cancer drug delivery carrier and applied for cell imaging. it is found that anti-cancer drug doxorubicin hydrochloride (dox) can be absorbed into ucnps@msio(2)-peg/fa nanospheres and released in a ph-sensitive pattern. in vitro cell cytotoxicity tests on cancer cells verified that dox-loaded ucnps@msio(2)-peg/fa nanospheres exhibited greater cytotoxicity with respect to free dox and dox-loaded ucnps@msio(2)-peg at the same concentrations, owing to the increase of cell uptake of anti-cancer drug delivery vehicles mediated by the fa receptor. moreover, the upconversion luminescence image of ucnps@msio(2)-peg/fa taken up by cells shows green emission under 980 nm infrared laser excitation, making the ucnps@msio(2)-peg/fa nanocomposite spheres promising candidates as bioimaging agents. these findings highlight the promise of the highly versatile multifunctional nanoparticles for simultaneous imaging and therapeutic applications. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000330133100009 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50120]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li CX,Hou ZY,Dai YL,et al. A facile fabrication of upconversion luminescent and mesoporous core- shell structured beta-NaYF4:Yb3+, Er3+@mSiO(2) nanocomposite spheres for anti-cancer drug delivery and cell imaging[J]. biomaterials science,2013,1(2):213-223. |
| APA | Li CX.,Hou ZY.,Dai YL.,Yang DM.,Cheng ZY.,...&Lin J.(2013).A facile fabrication of upconversion luminescent and mesoporous core- shell structured beta-NaYF4:Yb3+, Er3+@mSiO(2) nanocomposite spheres for anti-cancer drug delivery and cell imaging.biomaterials science,1(2),213-223. |
| MLA | Li CX,et al."A facile fabrication of upconversion luminescent and mesoporous core- shell structured beta-NaYF4:Yb3+, Er3+@mSiO(2) nanocomposite spheres for anti-cancer drug delivery and cell imaging".biomaterials science 1.2(2013):213-223. |
入库方式： OAI收割
来源：长春应用化学研究所
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