Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy
文献类型：期刊论文
| 作者 | Ding JX ; Shi FH ; Li D ; Chen L ; Zhuang XL ; Chen XS |
| 刊名 | biomaterials science
 |
| 出版日期 | 2013 |
| 卷号 | 1期号:6页码:633-646 |
| 关键词 | INTRACELLULAR DRUG-DELIVERY BLOCK-COPOLYMER POTENTIAL CARRIER IN-VITRO PH MICELLES RELEASE POLYMER CANCER DNA |
| ISSN号 | 2047-4830 |
| 通讯作者 | ding jx |
| 中文摘要 | three derivatives of doxorubicin (dox) were prepared by modifying dox with succinic anhydride, cisaconitic anhydride and 2,3-dimethylmaleic anhydride, generating acid-insensitive succinyl-dox (sad), acid-sensitive cis-aconityl-dox (cad) and 2,3-dimethylmaleyl-dox (dad) respectively. the ph and reduction dual-responsive methoxy poly(ethylene glycol)-poly(l-lysine-co-l-cystine) nanogel was employed to encapsulate the dox derivatives. in vitro release studies showed that drug release could be accelerated in the intracellular acidic and reductive conditions. confocal laser scanning microscopy and flow cytometry results demonstrated that an enhanced intracellular drug release was observed in glutathione monoester pretreated hela cells (a human cervical cell line). the dox derivatives exhibited a lower accumulation in the nuclei than dox. moreover, the cad and dad-loaded nanogels showed a comparable anti-proliferative activity to the dox-loaded nanogel against hela and hepg2 cells (a human hepatoma cell line). as a comparison, the sad-loaded nanogel almost never inhibited cellular proliferation. the above results suggested that the ph and reduction dual-responsive nanogel can efficiently deliver acid-sensitive dox derivatives into the nuclei of cancer cells for minimizing the side effects and enhancing the inhibition of cellular proliferation. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000330134900008 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50121]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ding JX,Shi FH,Li D,et al. Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy[J]. biomaterials science,2013,1(6):633-646. |
| APA | Ding JX,Shi FH,Li D,Chen L,Zhuang XL,&Chen XS.(2013).Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy.biomaterials science,1(6),633-646. |
| MLA | Ding JX,et al."Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy".biomaterials science 1.6(2013):633-646. |
入库方式： OAI收割
来源：长春应用化学研究所
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