Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems
文献类型：期刊论文
| 作者 | Yue J ; Liu S ; Xie ZG ; Xing Y ; Jing XB |
| 刊名 | journal of materials chemistry b
 |
| 出版日期 | 2013 |
| 卷号 | 1期号:34页码:4273-4280 |
| 关键词 | AMPHIPHILIC BLOCK-COPOLYMERS CANCER-THERAPY IN-VIVO NANOPARTICLES ACCUMULATION THERAPEUTICS CROSS |
| ISSN号 | 2050-750x |
| 通讯作者 | yue j |
| 中文摘要 | the fate of polymeric micelles (pms) is mainly determined by their physicochemical properties, such as particle size, shape, and surface potential. of these factors, the size effect of pms plays a fundamental role. in this study, four different sizes of pms with fluorescence-labeling were prepared to study the size-dependent biodistribution profiles as well as the anti-tumor efficacy in h22-subcutaneous hepatoma-bearing mice. both ex vivo tumor imaging and in vivo real-time near-infrared (nir) dye-tracking experiments indicated that sub-100 nm pms have a higher extent of accumulation in tumor sites than >100 nm pms. for normal tissues, smaller pms (35 nm) tend to accumulate in the kidney and larger pms (145 nm) tend to be captured by the spleen and lung, while middle-sized pms (75 and 115 nm) tend to accumulate in the liver. finally, doxorubicin (dox) was used as the model drug to study the size-dependent anti-tumor efficacy of dox-loaded micelles with h22-bearing mice and the results indicated that the smallest micellar drugs exhibited the best tumor-growth inhibition effect. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000322916400010 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50221]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yue J,Liu S,Xie ZG,et al. Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems[J]. journal of materials chemistry b,2013,1(34):4273-4280. |
| APA | Yue J,Liu S,Xie ZG,Xing Y,&Jing XB.(2013).Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems.journal of materials chemistry b,1(34),4273-4280. |
| MLA | Yue J,et al."Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems".journal of materials chemistry b 1.34(2013):4273-4280. |
入库方式： OAI收割
来源：长春应用化学研究所
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