A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps
文献类型：期刊论文
| 作者 | He HY ; Kuang HH ; Yan LS ; Meng FB ; Xie ZG ; Jing XB ; Huang YB |
| 刊名 | physical chemistry chemical physics
 |
| 出版日期 | 2013 |
| 卷号 | 15期号:34页码:14210-14218 |
| 关键词 | RESPONSIVE CONTROLLED-RELEASE ANTICANCER DRUG-DELIVERY GOLD NANOPARTICLES MOLECULES MICELLES CANCER CORE GENE |
| ISSN号 | 1463-9076 |
| 通讯作者 | meng fb |
| 中文摘要 | mesoporous silica nanoparticles (msn)-polymer hybrid combined with the aliphatic biodegradable polyester caps on the surface were first developed in order to manipulate the smart intracellular release of anticancer drugs. first, poly(ethylene glycol)-b-poly(epsilon-caprolactone) (peg-pcl) was successfully grafted on the surface of msn via disulfide bonds which could cleave under a reduction environment in tumor cells. the anticancer drug doxorubicin (dox) was encapsulated into the particle pores. the in vitro drug release profile showed that dox release was significantly restricted by the polymer caps at ph 7.4, while it was greatly accelerated upon the addition of gsh. cytotoxicity evaluation showed good biocompatibility with the hybrid particles. fast endocytosis and intracellular dox release were observed by confocal laser scanning microscopy (clsm). the dox-loaded particles exhibited comparable antitumor activity with free dox towards hela cells and showed in a time-dependent manner. this work developed an extensive method of utilizing aliphatic biodegradable polyesters as polymer caps for msn to control drug delivery. the paper might offer a potential option for cancer therapy. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000322725000008 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50223]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | He HY,Kuang HH,Yan LS,et al. A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps[J]. physical chemistry chemical physics,2013,15(34):14210-14218. |
| APA | He HY.,Kuang HH.,Yan LS.,Meng FB.,Xie ZG.,...&Huang YB.(2013).A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps.physical chemistry chemical physics,15(34),14210-14218. |
| MLA | He HY,et al."A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps".physical chemistry chemical physics 15.34(2013):14210-14218. |
入库方式： OAI收割
来源：长春应用化学研究所
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