Core-shell structured luminescent and mesoporous beta-NaYF4:Ce3+/Tb3+@mSiO(2)-PEG nanospheres for anti-cancer drug delivery
文献类型：期刊论文
| 作者 | Wu Y ; Yang DM ; Kang XJ ; Ma PA ; Huang SS ; Zhang Y ; Li CX ; Lin J |
| 刊名 | dalton transactions
 |
| 出版日期 | 2013 |
| 卷号 | 42期号:27页码:9852-9861 |
| 关键词 | UP-CONVERSION LUMINESCENT SILICA NANOPARTICLES CONTROLLED-RELEASE CARRIER SIZE NANOCOMPOSITES UNIFORM SPHERES FUNCTIONALIZATION MICROSPHERES |
| ISSN号 | 1477-9226 |
| 通讯作者 | li cx |
| 中文摘要 | multifunctional nanocomposites integrating mesoporous and luminescence properties into a single entity are synthesized via a facile and effective approach. oleic acid capped beta-nayf4:ce3+/tb3+ nanoparticles (nps) are transferred into aqueous solution by cetyltrimethylammonium bromide (ctab) surfactants, and further encapsulated with uniform mesoporous silica shell followed by the surface modification with poly(ethylene glycol) (peg), leading to the formation of water-dispersible and biocompatible core-shell structured beta-nayf4:ce3+/tb3+@msio(2)-peg (denoted as nps@msio(2)-peg) nanospheres. the as-synthesized nanospheres show a typical mesoporous structure and a green emission under uv irradiation. doxorubicin hydrochloride (dox), a widely used anti-cancer drug, is used as a model drug to evaluate the loading and controlled release behaviors of the nps@msio(2)-peg in phosphoric acidic buffer solutions (pbs) at different ph values (ph = 7.4 and 5.0). the composite carriers provide a ph-sensitive drug release pattern and the drug releases faster under lower ph value. the endocytosis process of fluorescein isothiocyanate (fitc)-labelled nanospheres is characterized using flow cytometry and confocal laser scanning microscopy (clsm) against a549 cells. the in vitro cytotoxic effect against a549 cells of the dox-loaded carriers is investigated in detail. in addition, the extent of drug release can be monitored by the variation of photoluminescence (pl) intensity of beta-nayf4:ce3+/tb3+. considering the good biocompatibility and ph-dependent drug release pattern, such core-shell structured luminescent nps@msio(2)-peg nanospheres have potential applications in controlled drug delivery. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000320559800011 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50264]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wu Y,Yang DM,Kang XJ,et al. Core-shell structured luminescent and mesoporous beta-NaYF4:Ce3+/Tb3+@mSiO(2)-PEG nanospheres for anti-cancer drug delivery[J]. dalton transactions,2013,42(27):9852-9861. |
| APA | Wu Y.,Yang DM.,Kang XJ.,Ma PA.,Huang SS.,...&Lin J.(2013).Core-shell structured luminescent and mesoporous beta-NaYF4:Ce3+/Tb3+@mSiO(2)-PEG nanospheres for anti-cancer drug delivery.dalton transactions,42(27),9852-9861. |
| MLA | Wu Y,et al."Core-shell structured luminescent and mesoporous beta-NaYF4:Ce3+/Tb3+@mSiO(2)-PEG nanospheres for anti-cancer drug delivery".dalton transactions 42.27(2013):9852-9861. |
入库方式： OAI收割
来源：长春应用化学研究所
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