Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy
文献类型：期刊论文
| 作者 | Wang DW ; Zhu XM ; Lee SF ; Chan HM ; Li HW ; Kong SK ; Yu JC ; Cheng CHK ; Wang YXJ ; Leung KCF |
| 刊名 | journal of materials chemistry b
 |
| 出版日期 | 2013 |
| 卷号 | 1期号:23页码:2934-2942 |
| 关键词 | IRON-OXIDE NANOPARTICLES GOLD NANORODS CELLULAR UPTAKE NANOCOMPOSITE MATERIALS OPTICAL-PROPERTIES CONTRAST AGENTS SILICA SPHERES CANCER-THERAPY TUMOR-CELLS IN-VITRO |
| ISSN号 | 2050-750x |
| 通讯作者 | wang dw |
| 中文摘要 | in this paper, we investigated the functional imaging and targeted therapeutic properties of core@multi-shell nanoparticles composed of a superparamagnetic iron oxide (spio) core and gold nanorods (gnrs) in the mesoporous silica shells functionalized with folic acid (fe3o4@sio2@gnrs@msio(2)-fa). the as-synthesized five-component hybrid nanocomposite was revealed to have insignificant cytotoxicity. intracellular uptake of the nanoparticles was studied in the folate receptor over-expressing human epidermoid carcinoma of the nasopharynx (kb) cells. due to their magnetic/optical properties as well as the folate targeting potential, compared with fe3o4@sio2@gnrs@msio(2) nanoparticles, higher cellular uptake efficiency was observed for fe3o4@sio2@gnrs@msio(2)-fa nanoparticles in kb cells. characterizations were achieved using both dark field and magnetic resonance (mr) imaging techniques. the hyperthermia induced by fe3o4@sio2@gnrs@msio(2)-fa nanoparticles resulted in a higher cytotoxicity in kb cells. thus, the fe3o4@sio2@gnrs@msio(2)-fa hybrid nanomaterial is an effective and promising mr imaging and photothermal therapy agent for folate-receptor over-expressing cancer cells. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319273100006 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50281]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang DW,Zhu XM,Lee SF,et al. Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy[J]. journal of materials chemistry b,2013,1(23):2934-2942. |
| APA | Wang DW.,Zhu XM.,Lee SF.,Chan HM.,Li HW.,...&Leung KCF.(2013).Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy.journal of materials chemistry b,1(23),2934-2942. |
| MLA | Wang DW,et al."Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy".journal of materials chemistry b 1.23(2013):2934-2942. |
入库方式： OAI收割
来源：长春应用化学研究所
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