A new method for identification of in vitro metabolites of 2,3,7,8-TCDD with rat liver microsomes by using liquid chromatography-mass spectrometry
文献类型：期刊论文
| 作者 | Wang CY ; Tang Z ; Zhang YL ; Liang Y ; Song FR ; Cai ZW |
| 刊名 | analytical methods
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:11页码:2757-2760 |
| 关键词 | DIBENZO-P-DIOXINS TCDD-METABOLITES 2 TOXICITY PCDDS MICE 3 7 8-TETRACHLORODIBENZO-PARA-DIOXIN |
| ISSN号 | 1759-9660 |
| 通讯作者 | cai zw |
| 中文摘要 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-tcdd) is known as a highly toxic environmental contaminant and poses potential risks to human and animal health. as a persistent organic pollutant, 2,3,7,8-tcdd is hard to metabolize and thus gets accumulated in the human and animal body. literature reports on the metabolism study of 2,3,7,8-tcdd are rare. the traditional method of gc-ms for 2,3,7,8-tcdd analysis might not be amenable for the direct analysis of its polar metabolites. in this study, in vitro metabolism of 2,3,7,8-tcdd with rat liver microsomes by using lc-ms and ms/ms was investigated and two hydroxylated metabolites of 2,3,7,8-tcdd and four trichloro-dihydroxydibenzo-p-dioxins were identified from the direct lc-ms and ms/ms analyses of the incubated samples. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319004800016 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50283]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang CY,Tang Z,Zhang YL,et al. A new method for identification of in vitro metabolites of 2,3,7,8-TCDD with rat liver microsomes by using liquid chromatography-mass spectrometry[J]. analytical methods,2013,5(11):2757-2760. |
| APA | Wang CY,Tang Z,Zhang YL,Liang Y,Song FR,&Cai ZW.(2013).A new method for identification of in vitro metabolites of 2,3,7,8-TCDD with rat liver microsomes by using liquid chromatography-mass spectrometry.analytical methods,5(11),2757-2760. |
| MLA | Wang CY,et al."A new method for identification of in vitro metabolites of 2,3,7,8-TCDD with rat liver microsomes by using liquid chromatography-mass spectrometry".analytical methods 5.11(2013):2757-2760. |
入库方式： OAI收割
来源：长春应用化学研究所
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