Thermo-responsive "hairy-rod" polypeptides for smart antitumor drug delivery
文献类型：期刊论文
| 作者 | Ding JX ; Zhao L ; Li D ; Xiao CS ; Zhuang XL ; Chen XS |
| 刊名 | polymer chemistry
 |
| 出版日期 | 2013 |
| 卷号 | 4期号:11页码:3345-3356 |
| 关键词 | RING-OPENING POLYMERIZATION GLYCOL) SIDE-CHAINS CLICK CHEMISTRY BIOMEDICAL APPLICATIONS MOLECULAR BRUSHES POLY(L-GLUTAMIC ACID) BLOCK COPOLYPEPTIDES N-CARBOXYANHYDRIDE FACILE SYNTHESIS MICELLES |
| ISSN号 | 1759-9954 |
| 通讯作者 | xiao cs |
| 中文摘要 | a series of thermo-responsive "hairy-rod" polypeptides was efficiently synthesized by grafting of azide-terminated (co)polymers of 2-(2-methoxyethoxy)ethyl methacrylate (meo(2)ma) or 2-(2-(2-methoxyethoxy) ethoxy) ethyl methacrylate (meo(3)ma) (i.e., n-3-pmeoima) onto poly(gamma-propargyl-l-glutamate) (pplg) through a "click" reaction. the thermo-responsiveness and secondary structure of the resultant polypeptides (i.e. plg-g-pmeo(i)ma) were shown to be dependent on the meo2ma : meo3ma ratio in pmeo(i)ma side chains. plg(40)-g-p(meo(2)ma(18)-co-meo(3)ma(9)) (p2) and plg40-g-p(meo(2)ma(7)-co-meo(3)ma(18)) (p4) with lower critical solution temperatures at 25.6 and 34.8 degrees c, and cloud points at 26.9 and 35.6 degrees c in physiological saline, respectively, were selected to self-assemble into micelles for doxorubicin (dox) loading and release. in vitro dox release from dox-loaded micelles could be accelerated by a decrease of temperature and ph. confocal laser scanning microscopy and flow cytometry confirmed the efficient internalization and intracellular dox release of dox-loaded micelles towards hela cells (a human cervical carcinoma cell line). in vitro methyl thiazolyl tetrazolium assays revealed that the polypeptides were cytocompatible, and dox-loaded micelles showed efficient cellular proliferation inhibition. hemolysis tests indicated that micelles were hemocompatible, and the encapsulation with polypeptides significantly reduced the hemolysis ratio of dox. therefore, the thermo-responsive polypeptide micelles, which are stable in physiological condition while releasing payloads in the acidic intracellular microenvironment, are promising for smart drug delivery. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000318557600020 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50293]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ding JX,Zhao L,Li D,et al. Thermo-responsive "hairy-rod" polypeptides for smart antitumor drug delivery[J]. polymer chemistry,2013,4(11):3345-3356. |
| APA | Ding JX,Zhao L,Li D,Xiao CS,Zhuang XL,&Chen XS.(2013).Thermo-responsive "hairy-rod" polypeptides for smart antitumor drug delivery.polymer chemistry,4(11),3345-3356. |
| MLA | Ding JX,et al."Thermo-responsive "hairy-rod" polypeptides for smart antitumor drug delivery".polymer chemistry 4.11(2013):3345-3356. |
入库方式： OAI收割
来源：长春应用化学研究所
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