PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity
文献类型：期刊论文
| 作者 | Liu Z ; Pu F ; Liu JH ; Jiang LY ; Yuan QH ; Li ZQ ; Ren JS ; Qu XG |
| 刊名 | nanoscale
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:10页码:4252-4261 |
| 关键词 | UP-CONVERSION NANOPARTICLES COATED GOLD NANOPARTICLES LARGE-SCALE SYNTHESIS CONTRAST AGENTS SILICA NANOPARTICLES DRUG-DELIVERY SULFIDE NANOPARTICLES HEMOLYTIC-ACTIVITY GADOLINIUM NANOCRYSTALS |
| ISSN号 | 2040-3364 |
| 通讯作者 | ren js |
| 中文摘要 | novel nanoparticulate contrast agents with low systemic toxicity and inexpensive character have exhibited more advantages over routinely used small molecular contrast agents for the diagnosis and prognosis of disease. herein, we designed and synthesized pegylated hybrid ytterbia nanoparticles as high-performance nanoprobes for x-ray computed tomography (ct) imaging and magnetic resonance (mr) imaging both in vitro and in vivo. these well-defined nanoparticles were facile to prepare and cost-effective, meeting the criteria as a biomedical material. compared with routinely used iobitridol in clinic, our peg-yb2o3:gd nanoparticles could provide much significantly enhanced contrast upon various clinical voltages ranging from 80 kvp to 140 kvp owing to the high atomic number and well-positioned k-edge energy of ytterbium. by the doping of gadolinium, our nanoparticulate contrast agent could perform perfect mr imaging simultaneously, revealing similar organ enrichment and bio-distribution with the ct imaging results. the super improvement in imaging efficiency was mainly attributed to the high content of yb and gd in a single nanoparticle, thus making these nanoparticles suitable for dual-modal diagnostic imaging with a low single-injection dose. in addition, detailed toxicological study in vitro and in vivo indicated that uniformly sized peg-yb2o3:gd nanoparticles possessed excellent biocompatibility and revealed overall safety. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000318362400032 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50298]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu Z,Pu F,Liu JH,et al. PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity[J]. nanoscale,2013,5(10):4252-4261. |
| APA | Liu Z.,Pu F.,Liu JH.,Jiang LY.,Yuan QH.,...&Qu XG.(2013).PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity.nanoscale,5(10),4252-4261. |
| MLA | Liu Z,et al."PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity".nanoscale 5.10(2013):4252-4261. |
入库方式： OAI收割
来源：长春应用化学研究所
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