A cross-linked polymeric micellar delivery system for cisplatin(IV) complex
文献类型：期刊论文
| 作者 | Song HQ ; Wang R ; Xiao HH ; Cai HD ; Zhang WJ ; Xie ZG ; Huang YB ; Jing XB ; Liu TJ |
| 刊名 | european journal of pharmaceutics and biopharmaceutics
 |
| 出版日期 | 2013 |
| 卷号 | 83期号:1页码:63-75 |
| 关键词 | BIODEGRADABLE NANOPARTICLES PLATINUM(IV) COMPLEXES DRUG-DELIVERY CELL-LINES REDUCTION GLUTATHIONE MECHANISM KINETICS PACLITAXEL CHEMISTRY |
| ISSN号 | 0939-6411 |
| 通讯作者 | jing xb |
| 中文摘要 | a polymeric cisplatin(iv) prodrug in the form of cross-linked micelles (m(pt(iv)) was prepared by first constructing mpeg-b-pcl-b-pll micelles and then attaching a cisplatin(iv) complex with two axial succinic moieties to the lysine residues of the carrier polymer in aqueous medium. the micelles obtained were characterized by tem, dls, and zeta potential measurement. their in vitro release experiments were carried out at ph 7.4 and 5.0 or in the presence of 5 mm sodium ascorbate (naasc). results showed that the micelles were sensitive to both acidic hydrolysis and mild reducing agents; in the presence of 5 mm naasc, cisplatin(ii) was directly released and the released cisplatin(ii) could chelate with nucleobases; the micelles displayed comparable cytotoxicities to cisplatin; and the micelles were much more efficiently internalized by the cells than cisplatin(ii) and cisplatin(iv) counterparts. moreover, in vivo study showed accumulation of more pt species in the tumor site and lower systematic toxicity compared to free cisplatin(ii) and cisplatin(iv). this polymeric prodrug of cisplatin is expected to be used more for future study and applications. (c) 2012 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000315305800008 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50356]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Song HQ,Wang R,Xiao HH,et al. A cross-linked polymeric micellar delivery system for cisplatin(IV) complex[J]. european journal of pharmaceutics and biopharmaceutics,2013,83(1):63-75. |
| APA | Song HQ.,Wang R.,Xiao HH.,Cai HD.,Zhang WJ.,...&Liu TJ.(2013).A cross-linked polymeric micellar delivery system for cisplatin(IV) complex.european journal of pharmaceutics and biopharmaceutics,83(1),63-75. |
| MLA | Song HQ,et al."A cross-linked polymeric micellar delivery system for cisplatin(IV) complex".european journal of pharmaceutics and biopharmaceutics 83.1(2013):63-75. |
入库方式： OAI收割
来源：长春应用化学研究所
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