Fabrication of poly(L-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering
文献类型：期刊论文
| 作者 | Yan SF ; Zhang KX ; Liu ZW ; Zhang X ; Gan L ; Cao B ; Chen XS ; Cui L ; Yin JB |
| 刊名 | journal of materials chemistry b
 |
| 出版日期 | 2013 |
| 卷号 | 1期号:11页码:1541-1551 |
| 关键词 | MESENCHYMAL STEM-CELLS CARTILAGE REPAIR GLUTAMIC-ACID PORE-SIZE CHITOSAN HYDROGELS ADHESION FILMS |
| ISSN号 | 2050-750x |
| 通讯作者 | yan sf |
| 中文摘要 | porous scaffolds composed of polypeptides and polysaccharides have remarkable biocompatibility and potential to mimic an extracellular matrix for tissue engineering. this study presented a novel design of polyelectrolyte complex porous scaffolds of a synthetic polypeptide poly(l-glutamic acid) (plga) and a natural polysaccharide chitosan (cs) using a freeze drying method. the microstructure of the porous scaffolds could be adjusted by changing the freezing temperature and solid content of the reacting polymer. plga/cs scaffolds fabricated from 2% solid content and at a freezing temperature of -20 degrees c exhibited an interconnected porous structure with average pore size between 150 and 200 mm. the contact angle of less than 75 degrees and high swelling ratio of more than 700% showed the excellent hydrophilic performance of these scaffolds. degradation of the plga/cs composite scaffolds could be modified and more cs content contributed a higher resistance to biodegradation. the mechanical properties of the scaffolds could be controlled by varying the plga/cs molar ratio and solid content. the scaffolds exhibited good elastic behavior in wet state. in vitro culture of rabbit adipose-derived stem cells (ascs) indicated that the selected plga/cs porous scaffolds supported cell attachment and growth. in summary, the plga/cs porous scaffolds show excellent properties, such as an interconnected porous structure, mechanical strength, hydrophilicity, biodegradability and biocompatibility. the successful repair of articular cartilage defects showed the potentiality of using plga/cs scaffolds in cartilage tissue engineering. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000315169000003 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50371]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yan SF,Zhang KX,Liu ZW,et al. Fabrication of poly(L-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering[J]. journal of materials chemistry b,2013,1(11):1541-1551. |
| APA | Yan SF.,Zhang KX.,Liu ZW.,Zhang X.,Gan L.,...&Yin JB.(2013).Fabrication of poly(L-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering.journal of materials chemistry b,1(11),1541-1551. |
| MLA | Yan SF,et al."Fabrication of poly(L-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering".journal of materials chemistry b 1.11(2013):1541-1551. |
入库方式： OAI收割
来源：长春应用化学研究所
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