Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery
文献类型：期刊论文
| 作者 | Chen ZW ; Li ZH ; Lin YH ; Yin ML ; Ren JS ; Qu XG |
| 刊名 | chemistry-a european journal
 |
| 出版日期 | 2013 |
| 卷号 | 19期号:5页码:1778-1783 |
| 关键词 | GUEST MOLECULES CANCER-THERAPY RELEASE CD44 RECEPTOR SYSTEM FUNCTIONALIZATION NANOVALVES CATABOLISM TRANSPORT |
| ISSN号 | 0947-6539 |
| 通讯作者 | ren js |
| 中文摘要 | in this paper, we present a facile strategy to synthesize hyaluronic acid (ha) conjugated mesoporous silica nanoparticles (msp) for targeted enzyme responsive drug delivery, in which the anchored ha polysaccharides not only act as capping agents but also as targeting ligands without the need of additional modification. the nanoconjugates possess many attractive features including chemical simplicity, high colloidal stability, good biocompatibility, cell-targeting ability, and precise cargo release, making them promising agents for biomedical applications. as a proof-of-concept demonstration, the nanoconjugates are shown to release cargoes from the interior pores of msps upon ha degradation in response to hyaluronidase-1 (hyal-1). moreover, after receptor-mediated endocytosis into cancer cells, the anchored ha was degraded into small fragments, facilitating the release of drugs to kill the cancer cells. overall, we envision that this system might open the door to a new generation of carrier system for site-selective, controlled-release delivery of anticancer drugs. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000313787700036 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50390]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen ZW,Li ZH,Lin YH,et al. Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery[J]. chemistry-a european journal,2013,19(5):1778-1783. |
| APA | Chen ZW,Li ZH,Lin YH,Yin ML,Ren JS,&Qu XG.(2013).Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery.chemistry-a european journal,19(5),1778-1783. |
| MLA | Chen ZW,et al."Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery".chemistry-a european journal 19.5(2013):1778-1783. |
入库方式： OAI收割
来源：长春应用化学研究所
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