Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms
文献类型：期刊论文
| 作者 | Zhang AP ; Zhang Z ; Shi FH ; Ding JX ; Xiao CS ; Zhuang XL ; He CL ; Chen L ; Chen XS |
| 刊名 | soft matter
 |
| 出版日期 | 2013 |
| 卷号 | 9期号:7页码:2224-2233 |
| 关键词 | TUMOR ACCUMULATION COPOLYMER MICELLES BLOCK-COPOLYMERS CANCER-THERAPY NANOPARTICLES DOXORUBICIN REDUCTION RELEASE GLUTATHIONE ASSEMBLIES |
| ISSN号 | 1744-683x |
| 通讯作者 | zhuang xl |
| 中文摘要 | novel reduction-responsive disulfide core-crosslinked micelles based on amphiphilic starch-graft-poly(ethylene glycol) (starch-g-peg) were prepared and used for efficient intracellular drug delivery. the starch-g-peg copolymers can be conveniently prepared by grafting starch with carboxyl group terminated peg, and subsequently conjugated with lipoic acid for disulfide crosslinking. the self-assembled starch-g-peg micelles and the corresponding disulfide core-crosslinked micelles were then characterized by transmission electron microscopy, dynamic laser scattering and fluorescence techniques. it is interesting to observe that the hydrodynamic radii of disulfide core-crosslinked micelles would increase gradually in phosphate buffered saline (pbs) due to the cleavage of the disulfide bond in the micellar core, caused by the presence of reductive glutathione (gsh). the glutathione-responsive behaviors of the disulfide core-crosslinked micelles should be attractive for intracellular drug delivery. thus, a model anticancer drug doxorubicin (dox) was loaded into micelles and the in vitro drug release in response to gsh was also studied. the results showed that only a small amount of loaded dox was released from the core-crosslinked starch-g-peg micelles in pbs solution without gsh, while quick release occurred in the presence of 10.0 mm gsh. confocal laser scanning microscopy and flow cytometry analyses further demonstrate that the disulfide crosslinked micelles exhibited a faster drug release behavior in glutathione monoester (gsh-oet) pretreated hela cells than that in the nonpretreated and buthionine sulfoximine (bso) pretreated cells. in addition, the dox-loaded crosslinked micelles show higher cellular proliferation inhibition against gsh-oet pretreated hela and hepg2 than against the nonpretreated and bso pretreated ones. these results suggest that such disulfide crosslinked starch-g-peg micelles, which can efficiently release the loading drug in response to intracellular gsh concentration, may provide favorable platforms for cancer therapy. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000313896900015 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50399]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang AP,Zhang Z,Shi FH,et al. Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms[J]. soft matter,2013,9(7):2224-2233. |
| APA | Zhang AP.,Zhang Z.,Shi FH.,Ding JX.,Xiao CS.,...&Chen XS.(2013).Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms.soft matter,9(7),2224-2233. |
| MLA | Zhang AP,et al."Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms".soft matter 9.7(2013):2224-2233. |
入库方式： OAI收割
来源：长春应用化学研究所
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