Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery
文献类型：期刊论文
| 作者 | Chen ZW ; Li ZH ; Lin YH ; Yin ML ; Ren JS ; Qu XG |
| 刊名 | biomaterials
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:4页码:1364-1371 |
| 关键词 | PHOSPHATE NANOCOMPOSITE PARTICLES CALCIUM-PHOSPHATE HYALURONIC-ACID MESOPOROUS SILICA HYDROXYAPATITE MINERALIZATION CONTROLLED-RELEASE GUEST MOLECULES CANCER-CELLS CD44 NANOPARTICLES |
| ISSN号 | 0142-9612 |
| 通讯作者 | ren js |
| 中文摘要 | recent insight into the molecular mechanisms of natural biomineralization has enabled biomimetic synthesis of functional organic-inorganic hybrid materials under mild reaction conditions. here, we describe a novel method to construct organic-inorganic hybrid on mesoporous silica nanoparticles by utilizing electrostatically absorbed hyaluronic acid (ha) as a reaction site for deposition of calcium phosphate (cap) minerals. the addition of another layer of ha on the cap surfaces not only stabilizes the nanocomposites but also confers target ability toward cd44 overexpressed cancer cells. the nanomaterials enable controlled release of loaded anticancer drugs in acidic subcellular environments after receptor mediated endocytosis. more importantly, our study demonstrated that the cancer targeting nanomaterials dramatically enhanced cellular uptake and cytotoxicity toward breast carcinoma cells. these results thus open new opportunities for biomineralization guided nanostructure assemblies with great potential for biomedical applications. (c) 2012 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000313155800049 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50406]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen ZW,Li ZH,Lin YH,et al. Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery[J]. biomaterials,2013,34(4):1364-1371. |
| APA | Chen ZW,Li ZH,Lin YH,Yin ML,Ren JS,&Qu XG.(2013).Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery.biomaterials,34(4),1364-1371. |
| MLA | Chen ZW,et al."Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery".biomaterials 34.4(2013):1364-1371. |
入库方式： OAI收割
来源：长春应用化学研究所
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