Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release
文献类型：期刊论文
| 作者 | Kang XJ ; Yang DM ; Dai YL ; Shang MM ; Cheng ZY ; Zhang X ; Lian HZ ; Ma PA ; Lin J |
| 刊名 | nanoscale
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:1页码:253-261 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES DELIVERY-SYSTEM HYBRID MICROSPHERES POLYMERIC MICELLES TARGETED DELIVERY CARGO RELEASE NANOCRYSTALS LUMINESCENT DOXORUBICIN DESIGN |
| ISSN号 | 2040-3364 |
| 通讯作者 | ma pa |
| 中文摘要 | in this study, multifunctional poly(acrylic acid) modified lanthanide-doped gdvo4 nanocomposites [paa@gdvo4: ln(3+) (ln = yb/er, yb/ho, yb/tm)] were constructed by filling paa hydrogel into gdvo4 hollow spheres via photoinduced polymerization. the up-conversion (uc) emission colors (green, red and blue) can be tuned by changing the codopant compositions in the matrices. the composites have potential applications as bio-probes for cell imaging. meanwhile, the hybrid spheres can act as t-1 contrast agents for magnetic resonance imaging (mri) owing to the existence of gd3+ ions on the surface of composites. due to the nature of paa, dox-loaded paa@gdvo4: yb3+/er3+ system exhibits ph-dependent drug releasing kinetics. a lower ph offers a faster drug release rate. such character makes the loaded dox easily released at cancer cells. the cell uptake process of drug-loaded composites was observed by using confocal laser scanning microscopy (clsm). the results indicate the potential application of the multifunctional composites as theragnostics (effective bimodal imaging probes and ph-responsive drug carriers). |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000313347200032 |
| 公开日期 | 2014-04-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50411]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kang XJ,Yang DM,Dai YL,et al. Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release[J]. nanoscale,2013,5(1):253-261. |
| APA | Kang XJ.,Yang DM.,Dai YL.,Shang MM.,Cheng ZY.,...&Lin J.(2013).Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release.nanoscale,5(1),253-261. |
| MLA | Kang XJ,et al."Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release".nanoscale 5.1(2013):253-261. |
入库方式： OAI收割
来源：长春应用化学研究所
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