Nanoceria-Triggered Synergetic Drug Release Based on CeO2-Capped Mesoporous Silica Host-Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2
文献类型：期刊论文
| 作者 | Xu C ; Lin YH ; Wang JS ; Wu L ; Wei WL ; Ren JS ; Qu XG |
| 刊名 | advanced healthcare materials
 |
| 出版日期 | 2013 |
| 卷号 | 2期号:12页码:1591-1599 |
| 关键词 | CERIUM OXIDE NANOPARTICLES RESPONSIVE CONTROLLED-RELEASE CARRIER SYSTEM DELIVERY THERAPY MCM-41 DAMAGE PH CYCLODEXTRINS MEDICINE |
| ISSN号 | 2192-2640 |
| 通讯作者 | qu xg |
| 中文摘要 | herein, a ph stimuli-responsive vehicle for intracellular drug delivery using ceo2 capped mesoporous silica nanoparticles (msn) is reported. -cyclodextrin-modified ceo2 nanoparticles could cap onto ferrocene-functionalized mesoporous silica through host-guest interactions. after internalization into a549 cells by a lysosomal pathway, the ferrocenyl moieties are oxidized to ferrocenium ions by ceo2 lids, which could trigger the uncapping of the ceo2 and cause the drugs release. because of the ph-dependent toxicity, the ceo2 here behaves as a multi-purpose entity that not only acts as a lid but also exhibits a synergistic antitumor effect on cancer cells. meanwhile, the cell protective effect of ceo2 nanoparticles alone is demonstrated, which ensures that the dissolved ceo2 nanoparticles can be non-toxic to normal cells. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000328344000007 |
| 公开日期 | 2014-04-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50452]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu C,Lin YH,Wang JS,et al. Nanoceria-Triggered Synergetic Drug Release Based on CeO2-Capped Mesoporous Silica Host-Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2[J]. advanced healthcare materials,2013,2(12):1591-1599. |
| APA | Xu C.,Lin YH.,Wang JS.,Wu L.,Wei WL.,...&Qu XG.(2013).Nanoceria-Triggered Synergetic Drug Release Based on CeO2-Capped Mesoporous Silica Host-Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2.advanced healthcare materials,2(12),1591-1599. |
| MLA | Xu C,et al."Nanoceria-Triggered Synergetic Drug Release Based on CeO2-Capped Mesoporous Silica Host-Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2".advanced healthcare materials 2.12(2013):1591-1599. |
入库方式： OAI收割
来源：长春应用化学研究所
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