Quantifying Waddington landscapes and paths of non-adiabatic cell fate decisions for differentiation, reprogramming and transdifferentiation
文献类型：期刊论文
| 作者 | Li CH ; Wang J |
| 刊名 | journal of the royal society interface
 |
| 出版日期 | 2013 |
| 卷号 | 10期号:89页码:文献号：20130787 |
| 关键词 | EMBRYONIC STEM-CELLS GENE-EXPRESSION SELF-RENEWAL POTENTIAL LANDSCAPE PLURIPOTENT STATE NETWORK MODEL OSCILLATIONS STABILITY TROPHECTODERM |
| ISSN号 | 1742-5662 |
| 通讯作者 | wang j |
| 中文摘要 | cellular differentiation, reprogramming and transdifferentiation are determined by underlying gene regulatory networks. non-adiabatic regulation via slow binding/unbinding to the gene can be important in these cell fate decision-making processes. based on a stem cell core gene network, we uncovered the stem cell developmental landscape. as the binding/unbinding speed decreases, the landscape topography changes from bistable attractors of stem and differentiated states to more attractors of stem and other different cell states as well as substates. non-adiabaticity leads to more differentiated cell types and provides a natural explanation for the heterogeneity observed in the experiments. we quantified waddington landscapes with two possible cell fate decision mechanisms by changing the regulation strength or regulation timescale (non-adiabaticity). transition rates correlate with landscape topography through barrier heights between different states and quantitatively determine global stability. we found the optimal speeds of these cell fate decision-making processes. we quantified biological paths and predict that differentiation and reprogramming go through an intermediate state (im1), whereas transdifferentiation goes through another intermediate state (im2). some predictions are confirmed by recent experimental studies. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000330302400014 |
| 公开日期 | 2014-04-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50454]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li CH,Wang J. Quantifying Waddington landscapes and paths of non-adiabatic cell fate decisions for differentiation, reprogramming and transdifferentiation[J]. journal of the royal society interface,2013,10(89):文献号：20130787. |
| APA | Li CH,&Wang J.(2013).Quantifying Waddington landscapes and paths of non-adiabatic cell fate decisions for differentiation, reprogramming and transdifferentiation.journal of the royal society interface,10(89),文献号：20130787. |
| MLA | Li CH,et al."Quantifying Waddington landscapes and paths of non-adiabatic cell fate decisions for differentiation, reprogramming and transdifferentiation".journal of the royal society interface 10.89(2013):文献号：20130787. |
入库方式： OAI收割
来源：长春应用化学研究所
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