中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Quantifying Waddington landscapes and paths of non-adiabatic cell fate decisions for differentiation, reprogramming and transdifferentiation

文献类型:期刊论文

作者Li CH ; Wang J
刊名journal of the royal society interface
出版日期2013
卷号10期号:89页码:文献号:20130787
关键词EMBRYONIC STEM-CELLS GENE-EXPRESSION SELF-RENEWAL POTENTIAL LANDSCAPE PLURIPOTENT STATE NETWORK MODEL OSCILLATIONS STABILITY TROPHECTODERM
ISSN号1742-5662
通讯作者wang j
中文摘要cellular differentiation, reprogramming and transdifferentiation are determined by underlying gene regulatory networks. non-adiabatic regulation via slow binding/unbinding to the gene can be important in these cell fate decision-making processes. based on a stem cell core gene network, we uncovered the stem cell developmental landscape. as the binding/unbinding speed decreases, the landscape topography changes from bistable attractors of stem and differentiated states to more attractors of stem and other different cell states as well as substates. non-adiabaticity leads to more differentiated cell types and provides a natural explanation for the heterogeneity observed in the experiments. we quantified waddington landscapes with two possible cell fate decision mechanisms by changing the regulation strength or regulation timescale (non-adiabaticity). transition rates correlate with landscape topography through barrier heights between different states and quantitatively determine global stability. we found the optimal speeds of these cell fate decision-making processes. we quantified biological paths and predict that differentiation and reprogramming go through an intermediate state (im1), whereas transdifferentiation goes through another intermediate state (im2). some predictions are confirmed by recent experimental studies.
收录类别SCI收录期刊论文
语种英语
WOS记录号WOS:000330302400014
公开日期2014-04-20
源URL[http://ir.ciac.jl.cn/handle/322003/50454]  
专题长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式
GB/T 7714
Li CH,Wang J. Quantifying Waddington landscapes and paths of non-adiabatic cell fate decisions for differentiation, reprogramming and transdifferentiation[J]. journal of the royal society interface,2013,10(89):文献号:20130787.
APA Li CH,&Wang J.(2013).Quantifying Waddington landscapes and paths of non-adiabatic cell fate decisions for differentiation, reprogramming and transdifferentiation.journal of the royal society interface,10(89),文献号:20130787.
MLA Li CH,et al."Quantifying Waddington landscapes and paths of non-adiabatic cell fate decisions for differentiation, reprogramming and transdifferentiation".journal of the royal society interface 10.89(2013):文献号:20130787.

入库方式: OAI收割

来源:长春应用化学研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。