Studies on Serum of Arsenic Trioxide Treated Rats by H-1 NMR Based Metabonomics
文献类型：期刊论文
| 作者 | Zhang PP ; Zhang WJ ; Xue R ; Li XJ ; Yan W ; Pei FK |
| 刊名 | chinese journal of analytical chemistry
 |
| 出版日期 | 2013 |
| 卷号 | 41期号:9页码:1434-1438 |
| 关键词 | OXIDATIVE STRESS CARCINOGENESIS SPECTROSCOPY METABOLISM INDUCTION TOXICITY SYSTEMS URINE CELLS ACID |
| ISSN号 | 0253-3820 |
| 通讯作者 | li xj |
| 中文摘要 | the metabolites of rats' serum caused by arsenic trioxide intragastric infusion (dosed at 2, 10 mg/kg body weight, respectively) were investigated through metabonomics. the metabolic profiling detected by nmr subjected to principal component analysis (pca), which find out the different metabolites of the control group and arsenic trioxide treated group, to explore the acute biological effects. the results revealed that arsenic trioxide caused acute damage on rats' liver, and the toxicity effect increased with the increase of dose. low dosage administration arsenic trioxide gave rise to reactive oxygen species (ros), and high dosage administration arsenic trioxide induced cell apoptosis. sugar, amino acid fat metabolism disorder and energy metabolism abnormality occurred in both low and high dosed rats. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000329520400020 |
| 公开日期 | 2014-04-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50465]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang PP,Zhang WJ,Xue R,et al. Studies on Serum of Arsenic Trioxide Treated Rats by H-1 NMR Based Metabonomics[J]. chinese journal of analytical chemistry,2013,41(9):1434-1438. |
| APA | Zhang PP,Zhang WJ,Xue R,Li XJ,Yan W,&Pei FK.(2013).Studies on Serum of Arsenic Trioxide Treated Rats by H-1 NMR Based Metabonomics.chinese journal of analytical chemistry,41(9),1434-1438. |
| MLA | Zhang PP,et al."Studies on Serum of Arsenic Trioxide Treated Rats by H-1 NMR Based Metabonomics".chinese journal of analytical chemistry 41.9(2013):1434-1438. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。