Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry
文献类型：期刊论文
| 作者 | Sui ZG ; Li N ; Liu ZQ ; Yan J ; Liu ZY |
| 刊名 | xenobiotica
 |
| 出版日期 | 2013 |
| 卷号 | 43期号:7页码:628-635 |
| 关键词 | HUMAN INTESTINAL BACTERIA TISSUE DISTRIBUTION MAIN METABOLITE ALKALOIDS RATS BIOTRANSFORMATION |
| ISSN号 | 0049-8254 |
| 通讯作者 | liu zy |
| 中文摘要 | 1. aconitine (ac), an active and highly toxic constituent extracted from aconitum plants, is well known for its excellent effects against rheumatism and rheumatoid arthritis. the metabolism of ac in liver and intestine has been previously reported. however, little is known about the metabolism of ac in stomach. in this study, the metabolite profiling of ac in stomachs of rabbit and rat was performed by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry (lc/esi/msn), for the first time. 2. the samples were purified by liquid-liquid extraction, separated using an agilent extended c18 column following a linear gradient elution and then detected by esi/msn in positive ion mode. metabolites were identified by comparing their protonated molecules, fragmentation patterns and chromatographic behaviors with those of standard compounds and data from authorized literature works. 3. in conclusion, 14 metabolites were identified in animal stomach after oral administration of ac. the presentation of a large amount of metabolites of ac in stomach suggested that, for aconitum alkaloids, the stomach might play an important role in their metabolism. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319881000007 |
| 公开日期 | 2014-04-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50475]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sui ZG,Li N,Liu ZQ,et al. Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry[J]. xenobiotica,2013,43(7):628-635. |
| APA | Sui ZG,Li N,Liu ZQ,Yan J,&Liu ZY.(2013).Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry.xenobiotica,43(7),628-635. |
| MLA | Sui ZG,et al."Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry".xenobiotica 43.7(2013):628-635. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。