Specificity and affinity quantification of protein-protein interactions
文献类型：期刊论文
| 作者 | Yan ZQ ; Guo LY ; Hu L ; Wang J |
| 刊名 | bioinformatics
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:9页码:1127-1133 |
| 关键词 | KNOWLEDGE-BASED POTENTIALS MEAN FORCE BINDING-AFFINITY COMPUTATIONAL REDESIGN MOLECULAR RECOGNITION SCORING FUNCTIONS DOCKING DESIGN PRINCIPLES PREDICTION |
| ISSN号 | 1367-4803 |
| 通讯作者 | wang j |
| 中文摘要 | motivation: most biological processes are mediated by the protein-protein interactions. determination of the protein-protein structures and insight into their interactions are vital to understand the mechanisms of protein functions. currently, compared with the isolated protein structures, only a small fraction of protein-protein structures are experimentally solved. therefore, the computational docking methods play an increasing role in predicting the structures and interactions of protein-protein complexes. the scoring function of protein-protein interactions is the key responsible for the accuracy of the computational docking. previous scoring functions were mostly developed by optimizing the binding affinity which determines the stability of the protein-protein complex, but they are often lack of the consideration of specificity which determines the discrimination of native protein-protein complex against competitive ones. results: we developed a scoring function (named as spa-pp, specificity and affinity of the protein-protein interactions) by incorporating both the specificity and affinity into the optimization strategy. the testing results and comparisons with other scoring functions show that spa-pp performs remarkably on both predictions of binding pose and binding affinity. thus, spa-pp is a promising quantification of protein-protein interactions, which can be implemented into the protein docking tools and applied for the predictions of protein-protein structure and affinity. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000318573900004 |
| 公开日期 | 2014-04-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50480]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yan ZQ,Guo LY,Hu L,et al. Specificity and affinity quantification of protein-protein interactions[J]. bioinformatics,2013,29(9):1127-1133. |
| APA | Yan ZQ,Guo LY,Hu L,&Wang J.(2013).Specificity and affinity quantification of protein-protein interactions.bioinformatics,29(9),1127-1133. |
| MLA | Yan ZQ,et al."Specificity and affinity quantification of protein-protein interactions".bioinformatics 29.9(2013):1127-1133. |
入库方式： OAI收割
来源：长春应用化学研究所
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