Selective Induction of Apoptosis: Promising Therapy in Pancreatic Cancer
文献类型：期刊论文
| 作者 | Liu ZJ ; Li D ; Zheng XL ; Wang EK ; Wang J |
| 刊名 | current pharmaceutical design
 |
| 出版日期 | 2013 |
| 卷号 | 19期号:12页码:2259-2268 |
| 关键词 | PHASE-III TRIAL GROWTH-FACTOR RECEPTOR COOPERATIVE-ONCOLOGY-GROUP MONOCLONAL-ANTIBODY CYTOCHROME-C CELL-DEATH MOLECULAR-MECHANISMS MEDIATED MECHANISM ANTITUMOR-ACTIVITY COLORECTAL-CANCER |
| ISSN号 | 1381-6128 |
| 通讯作者 | wang ek |
| 中文摘要 | pancreatic cancer is one of lethal and poor prognostic malignancies. due to the absence of effective detecting methods, quite a number of efforts have been made to improve a survival advantage for treatment in patients with pancreatic cancer. over the past decade, single-agent gemcitabine and gemcitabine-containing combinations were considered standard first-line therapies for advanced pancreatic cancer. although these routine uses of chemotherapy failed to significantly improve survival benefit for most therapies, these trials provided insights into the molecular mechanisms involved in the development of pancreatic cancer and therefore opened up new therapeutic avenues. apoptotic inducer as a therapeutic concept has been widely proposed and experimentally identified in some works. some reviews have revealed that apoptosis-inducing was a promising therapy in cancers with the least side effects and more effectiveness. apoptosis is a highly controlled physiological mechanism and proceeds through two major pathways for apoptosis-inducing. some anticancer drugs kill cancer cells by inducing apoptosis via death receptor pathway; however, other chemotherapeutic drugs trigger apoptosis via mitochondrial pathway. in this review, we summarize briefly current chemotherapy in pancreatic cancer, describe the apoptotic mechanisms, and provide a novel therapeutic strategy by targeting ras intermediate. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000316457700013 |
| 公开日期 | 2014-04-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50489]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu ZJ,Li D,Zheng XL,et al. Selective Induction of Apoptosis: Promising Therapy in Pancreatic Cancer[J]. current pharmaceutical design,2013,19(12):2259-2268. |
| APA | Liu ZJ,Li D,Zheng XL,Wang EK,&Wang J.(2013).Selective Induction of Apoptosis: Promising Therapy in Pancreatic Cancer.current pharmaceutical design,19(12),2259-2268. |
| MLA | Liu ZJ,et al."Selective Induction of Apoptosis: Promising Therapy in Pancreatic Cancer".current pharmaceutical design 19.12(2013):2259-2268. |
入库方式： OAI收割
来源：长春应用化学研究所
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