中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A Urinary Metabonomics Research on Total Ginsenoside Treated Diabetes Cardiomyopathy Rats Based on Rapid Resolution Liquid Chromatography/Mass Spectrometry

文献类型:期刊论文

作者Gu JN ; Niu J ; Pi ZF ; Yue H ; Wu SS ; Liu SY
刊名chinese journal of analytical chemistry
出版日期2013
卷号41期号:3页码:371-376
关键词MASS SPECTROMETRY TOXICITY SERUM SPECTROSCOPY CIRRHOSIS RISK NMR
ISSN号0253-3820
通讯作者wu ss
中文摘要a urinary metabonomics method based on rapid resolution liquid chromatography/mass spectrometry (rrlc/ms) was developed to study the effect mechanism of total ginsenoside (tg) on streptozotocin(stz) induced diabetic cardiomyopathy (dcm) rats. twenty-four stz-induced diabetic rats were randomly divided into dcm group and tg group. dcm group was administrated with tg 30 mg/kg body weight once a day by gastric irrigation. tg group was administrated with water by gastric irrigation in parallel. ten healthy rats were defined as control group and were also administrated with water by gastric irrigation in parallel. after twelve-week continuous irrigation, 24 h urine samples of rats in the three group were collected and analyzed by rrlc/ms. principal component analysis (pca) was carried out for pattern recognition and a clear separation between dcm rats and those treated with tg was achieved. three potential biomarkers were found and identified. the significant changes of these biomarkers indicated the pharmacological effects of tg on the metabolism of rats. tg can regulate the metabolism of body include citrate cycle, fatty acid metabolism and oxidative stress. the results shows the metabonomics is a useful tool in effect mechanism research of natural product and this work is helpful in the effect mechanism study of panax ginseng.
收录类别SCI收录期刊论文
语种中文
WOS记录号WOS:000318745100010
公开日期2014-04-20
源URL[http://ir.ciac.jl.cn/handle/322003/50491]  
专题长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式
GB/T 7714
Gu JN,Niu J,Pi ZF,et al. A Urinary Metabonomics Research on Total Ginsenoside Treated Diabetes Cardiomyopathy Rats Based on Rapid Resolution Liquid Chromatography/Mass Spectrometry[J]. chinese journal of analytical chemistry,2013,41(3):371-376.
APA Gu JN,Niu J,Pi ZF,Yue H,Wu SS,&Liu SY.(2013).A Urinary Metabonomics Research on Total Ginsenoside Treated Diabetes Cardiomyopathy Rats Based on Rapid Resolution Liquid Chromatography/Mass Spectrometry.chinese journal of analytical chemistry,41(3),371-376.
MLA Gu JN,et al."A Urinary Metabonomics Research on Total Ginsenoside Treated Diabetes Cardiomyopathy Rats Based on Rapid Resolution Liquid Chromatography/Mass Spectrometry".chinese journal of analytical chemistry 41.3(2013):371-376.

入库方式: OAI收割

来源:长春应用化学研究所

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