ABSORPTION OF HYPACONITINE AND P-GLYCOPROTEIN-MEDIATED DRUG-HYPACONITINE INTERACTIONS BY CACO-2 HUMAN INTESTINAL CELL MONOLAYERS
文献类型：期刊论文
| 作者 | Han TJ ; Liu Y ; Pi ZF ; Liu ZY ; Song FR ; Liu ZQ |
| 刊名 | journal of liquid chromatography & related technologies
 |
| 出版日期 | 2013 |
| 卷号 | 36期号:9页码:1207-1220 |
| 关键词 | ACONITUM ALKALOIDS INGESTION TOXICITY |
| ISSN号 | 1082-6076 |
| 通讯作者 | liu zq |
| 中文摘要 | aconitum species is an essential but toxic herb in traditional chinese medicine (tcm). as a main and characteristic constituent in aconitum species, hypaconitine (ha) was selected to illustrate the p-glycoprotein-mediated drug-ha interactions using caco-2 cell monolayers. the ha absorption results revealed that ha was not only an inhibiter but also a substance of p-glycoprotein (p-gp). in tcm theory, it is acknowledged that aconitum species are incompatible with bulbus fritillariae for the increase of the poisoning risk. peimine and peiminine, which are the active components of bulbus fritillariae, increased the bioavailability of ha suggested this effect should be one of the reason to increase the poisoning risk when bulbus fritillariae combined with aconitum species. however, no significant difference in absorption of peimine (pe) or peiminine (pen) was observed when they combined with ha, respectively. glycyrrhiza is a famous detoxifying herb in tcm, and the combined use of glycyrrhiza and aconitum species is a safe pair in tcm formulations. liquiritin (lq) and isoliquiritin (ilq), which are the active components of glycyrrhiza, were combined with ha, respectively. the detoxified mechanism of glycyrrhiza combined with aconitum species seems less related to the interaction of the absorption. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000317274800005 |
| 公开日期 | 2014-04-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50492]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Han TJ,Liu Y,Pi ZF,et al. ABSORPTION OF HYPACONITINE AND P-GLYCOPROTEIN-MEDIATED DRUG-HYPACONITINE INTERACTIONS BY CACO-2 HUMAN INTESTINAL CELL MONOLAYERS[J]. journal of liquid chromatography & related technologies,2013,36(9):1207-1220. |
| APA | Han TJ,Liu Y,Pi ZF,Liu ZY,Song FR,&Liu ZQ.(2013).ABSORPTION OF HYPACONITINE AND P-GLYCOPROTEIN-MEDIATED DRUG-HYPACONITINE INTERACTIONS BY CACO-2 HUMAN INTESTINAL CELL MONOLAYERS.journal of liquid chromatography & related technologies,36(9),1207-1220. |
| MLA | Han TJ,et al."ABSORPTION OF HYPACONITINE AND P-GLYCOPROTEIN-MEDIATED DRUG-HYPACONITINE INTERACTIONS BY CACO-2 HUMAN INTESTINAL CELL MONOLAYERS".journal of liquid chromatography & related technologies 36.9(2013):1207-1220. |
入库方式： OAI收割
来源：长春应用化学研究所
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