中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres

文献类型:期刊论文

作者Zhao TY ; Zhao JP ; Lei LY ; Chen XG ; Wang LC ; Chen XS ; Wang LP
刊名chemical journal of chinese universities-chinese
出版日期2013
卷号34期号:1页码:236-241
关键词DOUBLE-EMULSION METHOD ORAL INSULIN DELIVERY CHITOSAN MICROSPHERES DRUG-RELEASE PLGA NANOPARTICLES CELLS
ISSN号0251-0790
通讯作者wang lp
中文摘要two polyester microspheres were prepared by a water-in-oil-in-water( w-1/o/w-2) double emulsion solvent evaporation and deuterohaemin-beta-ahtvek(dhhp-6) was encapsulated to the polyester microspheres by a technique with good sphericity and high efficiency. the in vitro release profiles and in vivo biological activity of the polyester microspheres were evaluated by scanning electron microscope(sem), in vitro release, high performance liquid(hplc), enzyme activity detection and animal experiments. the data suggested that the drug-loaded polyester microspheres were spherical morphology with narrow size distribution, and had high entrapment capacity with great in vitro release profiles. furthermore, the drug-loaded polyester microspheres had protective effects on cell injury induced by hydrogen peroxide and cerebral ischemic injury in mice.
收录类别SCI收录期刊论文
语种中文
WOS记录号WOS:000317085300037
公开日期2014-04-20
源URL[http://ir.ciac.jl.cn/handle/322003/50502]  
专题长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式
GB/T 7714
Zhao TY,Zhao JP,Lei LY,et al. Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres[J]. chemical journal of chinese universities-chinese,2013,34(1):236-241.
APA Zhao TY.,Zhao JP.,Lei LY.,Chen XG.,Wang LC.,...&Wang LP.(2013).Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres.chemical journal of chinese universities-chinese,34(1),236-241.
MLA Zhao TY,et al."Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres".chemical journal of chinese universities-chinese 34.1(2013):236-241.

入库方式: OAI收割

来源:长春应用化学研究所

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