Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres
文献类型：期刊论文
| 作者 | Zhao TY ; Zhao JP ; Lei LY ; Chen XG ; Wang LC ; Chen XS ; Wang LP |
| 刊名 | chemical journal of chinese universities-chinese
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:1页码:236-241 |
| 关键词 | DOUBLE-EMULSION METHOD ORAL INSULIN DELIVERY CHITOSAN MICROSPHERES DRUG-RELEASE PLGA NANOPARTICLES CELLS |
| ISSN号 | 0251-0790 |
| 通讯作者 | wang lp |
| 中文摘要 | two polyester microspheres were prepared by a water-in-oil-in-water( w-1/o/w-2) double emulsion solvent evaporation and deuterohaemin-beta-ahtvek(dhhp-6) was encapsulated to the polyester microspheres by a technique with good sphericity and high efficiency. the in vitro release profiles and in vivo biological activity of the polyester microspheres were evaluated by scanning electron microscope(sem), in vitro release, high performance liquid(hplc), enzyme activity detection and animal experiments. the data suggested that the drug-loaded polyester microspheres were spherical morphology with narrow size distribution, and had high entrapment capacity with great in vitro release profiles. furthermore, the drug-loaded polyester microspheres had protective effects on cell injury induced by hydrogen peroxide and cerebral ischemic injury in mice. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 中文 |
| WOS记录号 | WOS:000317085300037 |
| 公开日期 | 2014-04-20 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50502]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao TY,Zhao JP,Lei LY,et al. Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres[J]. chemical journal of chinese universities-chinese,2013,34(1):236-241. |
| APA | Zhao TY.,Zhao JP.,Lei LY.,Chen XG.,Wang LC.,...&Wang LP.(2013).Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres.chemical journal of chinese universities-chinese,34(1),236-241. |
| MLA | Zhao TY,et al."Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres".chemical journal of chinese universities-chinese 34.1(2013):236-241. |
入库方式： OAI收割
来源：长春应用化学研究所
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