Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus
文献类型：期刊论文
| 作者 | Huang Sheng-Xiong ; Powell Emily ; Rajski Scott R ; Xu Wei ; Zhao Li-Xing ; Jiang Cheng-Lin ; Duan Yanwen ; Shen Ben* |
| 刊名 | Org. Lett
 |
| 出版日期 | 2010 |
| 期号 | 12页码:3525-3527 |
| 英文摘要 | Estrogen receptor ERr and ER heterodimerization has been implicated in cancer chemoprevention. The discovery, structural elucidation, and total synthesis of a new natural product, actinopolymorphol A (1), from Actinopolymorpha rutilus (YIM45725) that preferentially induces ERr/ heterodimerization is reported. Total synthesis of 1 has allowed us to determine its absolute stereochemistry and that of a previously known deacetylated congener, and 1 represents the first member of a new class of natural products not previously recognized to modulate ER function. |
| 收录类别 | SCI |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18021]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Huang Sheng-Xiong,Powell Emily,Rajski Scott R,et al. Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus[J]. Org. Lett,2010(12):3525-3527. |
| APA | Huang Sheng-Xiong.,Powell Emily.,Rajski Scott R.,Xu Wei.,Zhao Li-Xing.,...&Shen Ben*.(2010).Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus.Org. Lett(12),3525-3527. |
| MLA | Huang Sheng-Xiong,et al."Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus".Org. Lett .12(2010):3525-3527. |
入库方式： OAI收割
来源：昆明植物研究所
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