Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli
文献类型：期刊论文
| 作者 | Shi, HL
|
| 刊名 | JOURNAL OF THEORETICAL BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 314期号:-页码:164-172 |
| 关键词 | SEQUENTIAL BINDING AUTO-REGULATION DIVISION CYCLE GENE PROMOTER ADP-DNAA ORIGIN SITES MODEL K-12 SEQA |
| ISSN号 | 0022-5193 |
| 通讯作者 | Shi, HL (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China. |
| 英文摘要 | The initiation of chromosomal replication is strictly controlled during the cell cycle. Its frequency needs to be well-matched to the proliferation rate. In many bacteria, DnaA is the critical mediator in the regulation of replication initiation. In this work, the initiation probability is deduced based on the distribution of DnaA boxes at oriC in Escherichia coli. Taking into account more details, we develop a dynamic model to describe the oscillation of DnaA accompanied with the cell cycles. Our simulations show that the regulation of DnaA couples chromosomal replication to cell growth. We also discuss effects of other factors on DnaA oscillation. We propose that RNA polymerase is one of the candidates for harmonizing chromosomal replication and cell growth by adjusting dnaA transcriptional activity. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Physics |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] |
| 原文出处 | http://dx.doi.org/10.1016/j.jtbi.2012.08.045 |
| 语种 | 英语 |
| WOS记录号 | WOS:000310652900017 |
| 公开日期 | 2014-04-24 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/14958]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 推荐引用方式 GB/T 7714 | Shi, HL. Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli[J]. JOURNAL OF THEORETICAL BIOLOGY,2012,314(-):164-172. |
| APA | Shi, HL.(2012).Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli.JOURNAL OF THEORETICAL BIOLOGY,314(-),164-172. |
| MLA | Shi, HL."Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli".JOURNAL OF THEORETICAL BIOLOGY 314.-(2012):164-172. |
入库方式： OAI收割
来源：理论物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。