A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube
文献类型：期刊论文
| 作者 | Li, M
|
| 刊名 | COMMUNICATIONS IN THEORETICAL PHYSICS
 |
| 出版日期 | 2013 |
| 卷号 | 60期号:6页码:753-760 |
| 关键词 | MOLECULAR MOTORS LIVING CELLS DYNAMICS TRANSPORT |
| ISSN号 | 0253-6102 |
| 通讯作者 | Li, M (reprint author), Univ Chinese Acad Sci, Coll Phys Sci, Beijing 100049, Peoples R China. |
| 英文摘要 | Membrane tubes are important functional elements for living cells. Experiments have found that membrane tubes can be extracted from giant lipid vesicles by groups of kinesin. How these motors cooperate in extracting the membrane tube is a very important issue but still unclear so far. In this paper, we propose a cooperation mechanism called two-track-dumbbell model, in which kinesin is regarded as a dumbbell with an end (tail domain) tethered on the fluid-like membrane and the other end (head domain) stepping on the microtubule. Taking account of the elasticity of kinesin molecule and the excluded volume effect of both the head domain and the tail domain of kinesin, which are not considered in previous models, we simulate the growth process of the membrane tube pulled by kinesin motors. Our results indicate that in the case of strong or moderate exclusion of motor tails, the average number of motors pulling the tube can be as high as 9 and thus motors moving along a single microtubule protofilament can generate enough force to extract membrane tubes from vesicles. This result is different from previous studies and may be tested by future experiments. |
| 学科主题 | Physics |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] |
| 语种 | 英语 |
| WOS记录号 | WOS:000330882300020 |
| 公开日期 | 2014-04-25 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/15217]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 推荐引用方式 GB/T 7714 | Li, M. A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2013,60(6):753-760. |
| APA | Li, M.(2013).A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube.COMMUNICATIONS IN THEORETICAL PHYSICS,60(6),753-760. |
| MLA | Li, M."A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube".COMMUNICATIONS IN THEORETICAL PHYSICS 60.6(2013):753-760. |
入库方式： OAI收割
来源：理论物理研究所
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