Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule
文献类型：期刊论文
| 作者 | Zhang, YX |
| 刊名 | JOURNAL OF STATISTICAL PHYSICS
 |
| 出版日期 | 2013 |
| 卷号 | 152期号:6页码:1207-1221 |
| 关键词 | HAND-OVER-HAND CYTOPLASMIC DYNEIN MYOSIN-V EXCLUSION PROCESS MOTOR MOTILITY DISEASE WALKS |
| ISSN号 | 0022-4715 |
| 通讯作者 | Zhang, YX (reprint author), Fudan Univ, Shanghai Key Lab Contemporary Appl Math, Ctr Computat Syst Biol, Sch Math Sci, Shanghai 200433, Peoples R China. |
| 英文摘要 | Recently, a three-state model is presented to describe the intracellular traffic of unconventional (single-headed) kinesin KIF1A (Phys. Rev. Lett. 95:118101, 2005), in which each motor can bind strongly or weakly to its microtubule track, and each binding site of the track might be empty or occupied by one motor. As the usual two-state model, i.e. the totally asymmetric simple exclusion process (TASEP) with motor detachment and attachment, in steady state of the system, this three-state model also exhibits shock (or domain wall separating the high-density and low density phases) and boundary layers. In this study, using mean-field analysis, the conditions of existence of shock and boundary layers are obtained theoretically. Combined with numerical calculations, the properties of shock are also studied. This study will be helpful to understand the biophysical properties of the collective transport of kinesin KIF1A. |
| 学科主题 | Physics |
| 收录类别 | SCI |
| 资助信息 | Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] |
| 原文出处 | http://dx.doi.org/10.1007/s10955-013-0804-y |
| 语种 | 英语 |
| WOS记录号 | WOS:000323203800009 |
| 公开日期 | 2014-04-25 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/15290]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 推荐引用方式 GB/T 7714 | Zhang, YX. Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule[J]. JOURNAL OF STATISTICAL PHYSICS,2013,152(6):1207-1221. |
| APA | Zhang, YX.(2013).Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule.JOURNAL OF STATISTICAL PHYSICS,152(6),1207-1221. |
| MLA | Zhang, YX."Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule".JOURNAL OF STATISTICAL PHYSICS 152.6(2013):1207-1221. |
入库方式： OAI收割
来源：理论物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。