A Universal Law for Cell Uptake of One-Dimensional Nanomaterials
文献类型：期刊论文
| 作者 | Yi, X; Shi XH(施兴华) ; Gao HJ(高华健)
|
| 刊名 | Nano Letters
 |
| 出版日期 | 2014-02 |
| 卷号 | 14期号:2页码:1049-1055 |
| 通讯作者邮箱 | huajian_gao@brown.edu |
| ISSN号 | 1530-6984 |
| 关键词 | bulk shear strength of adhesive overall strength toughness adhesive thickness |
| 通讯作者 | Gao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA. |
| 产权排序 | [Yi, Xin; Gao, Huajian] Brown Univ, Sch Engn, Providence, RI 02912 USA; [Shi, Xinghua] Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China |
| 合作状况 | 国内 |
| 中文摘要 | Understanding cell interaction with one-dimensional nanomaterials, including nanotubes, nanowires, nanofibers, filamentous bacteria, and certain nanoparticle chains, has fundamental importance to many applications such as biomedical diagnostics, therapeutics, and nanotoxicity. Here we show that cell uptake of one-dimensional nanomaterials via receptor-mediated endocytosis is dominated by a single dimensionless parameter that scales with the membrane tension and radius of the nanomaterial and inversely with the membrane bending stiffness. It is shown that as cell membrane internalizes one-dimensional nanomaterials the uptake follows a near-perpendicular entry mode at small membrane tension but it switches to a near-parallel interaction mode at large membrane tension. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 分类号 | 一类 |
| 资助信息 | X.Y. and H.C. acknowledge support by the National Science Foundation under INSPIRE: "Computational Design for the Safe Development of High-Aspect-Ratio Nanomaterials", GBET-1344097, and one of its predecessor grants, CMMI-1028530; X.S. acknowledges support by the National Natural Science Foundation of China (Grant 11272327 and 11023001). |
| 收录类别 | SCI ; EI |
| 原文出处 | http://dx.doi.org/10.1021/nl404727m |
| 语种 | 英语 |
| WOS记录号 | WOS:000331343900101 |
| 公开日期 | 2014-05-09 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/48768]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yi, X,Shi XH,Gao HJ. A Universal Law for Cell Uptake of One-Dimensional Nanomaterials[J]. Nano Letters,2014,14(2):1049-1055. |
| APA | Yi, X,Shi XH,&Gao HJ.(2014).A Universal Law for Cell Uptake of One-Dimensional Nanomaterials.Nano Letters,14(2),1049-1055. |
| MLA | Yi, X,et al."A Universal Law for Cell Uptake of One-Dimensional Nanomaterials".Nano Letters 14.2(2014):1049-1055. |
入库方式： OAI收割
来源：力学研究所
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