Computational Study of Drugs by Integrating Omics Data with Kernel Methods
文献类型：期刊论文
| 作者 | Wang, Yongcui C.1; Deng, Naiyang2; Chen, Shilong1 ; Wang, Yong3,4
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| 刊名 | molecular informatics
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| 出版日期 | 2013-12-01 |
| 卷号 | 32期号:11-12页码:930-941 |
| 关键词 | Omics data Kernel methods Data integration Drug-targets ATC-codes of drugs Drug repositioning |
| ISSN号 | 1868-1743 |
| 通讯作者 | wang, ycc (reprint author), chinese acad sci, northwest inst plateau biol, key lab adaptat & evolut plateau biota, 23 xinning rd, xining, qinghai provinc, peoples r china. |
| 中文摘要 | with the rapid development of genomic and chemogenomic techniques, many omics data sources for drugs have been publicly available. these data sources illustrate drug's biological function in the living cell from different levels and different aspects. one straightforward idea is to learn understandable rules via computational models and algorithms to mine and integrate these data sources. here, we review our recent efforts on developing kernel-based methods to integrate drug related omics data sources. three promising applications of our framework are shown to predict drug targets, assign drug's atc-code annotation, and reveal drug repositioning. we demonstrate that data integration does provide more information and improve the accuracy by recovering more experimentally observed target proteins, atc-codes, and drug repositioning. importantly, data integration can indicate novel predictions which are supported by database search and functional annotation analysis and worthy of further experimental validation. in conclusion, kernel methods can efficiently integrate heterogeneous data sources to computationally study drugs, and will promote the further research in drug discovery in a low-cost way. |
| 英文摘要 | with the rapid development of genomic and chemogenomic techniques, many omics data sources for drugs have been publicly available. these data sources illustrate drug's biological function in the living cell from different levels and different aspects. one straightforward idea is to learn understandable rules via computational models and algorithms to mine and integrate these data sources. here, we review our recent efforts on developing kernel-based methods to integrate drug related omics data sources. three promising applications of our framework are shown to predict drug targets, assign drug's atc-code annotation, and reveal drug repositioning. we demonstrate that data integration does provide more information and improve the accuracy by recovering more experimentally observed target proteins, atc-codes, and drug repositioning. importantly, data integration can indicate novel predictions which are supported by database search and functional annotation analysis and worthy of further experimental validation. in conclusion, kernel methods can efficiently integrate heterogeneous data sources to computationally study drugs, and will promote the further research in drug discovery in a low-cost way. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal ; mathematical & computational biology |
| 研究领域[WOS] | pharmacology & pharmacy ; mathematical & computational biology |
| 关键词[WOS] | protein interaction prediction ; target relationships ; sequence ; identification ; knowledgebase ; similarity ; machine ; genes |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330109500006 |
| 公开日期 | 2014-05-09 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/3890]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Qinghai Provinc, Peoples R China 2.China Agr Univ, Coll Sci, Beijing 100094, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing, Peoples R China 4.Natl Inst Adv Ind Sci & Technol, Mol Profiling Res Ctr Drug Discovery, Tokyo, Japan |
| 推荐引用方式 GB/T 7714 | Wang, Yongcui C.,Deng, Naiyang,Chen, Shilong,et al. Computational Study of Drugs by Integrating Omics Data with Kernel Methods[J]. molecular informatics,2013,32(11-12):930-941. |
| APA | Wang, Yongcui C.,Deng, Naiyang,Chen, Shilong,&Wang, Yong.(2013).Computational Study of Drugs by Integrating Omics Data with Kernel Methods.molecular informatics,32(11-12),930-941. |
| MLA | Wang, Yongcui C.,et al."Computational Study of Drugs by Integrating Omics Data with Kernel Methods".molecular informatics 32.11-12(2013):930-941. |
入库方式： OAI收割
来源：西北高原生物研究所
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