EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE
文献类型：期刊论文
| 作者 | Zhao, Xiao-Hui1,2,3; Yue, Hui-Lan1; Li, Ping4; Zeng, Xin4; Zhang, Gen5 |
| 刊名 | nano
 |
| 出版日期 | 2013-06-01 |
| 卷号 | 8期号:3 |
| 关键词 | Quantum dots apoptosis caspase 3 verbascoside |
| ISSN号 | 1793-2920 |
| 通讯作者 | zeng, x (reprint author), nanjing med univ, nanjing matern & child hlth care hosp, state key lab reprod med, dept gynecol endocrine, nanjing 210029, jiangsu, peoples r china. |
| 中文摘要 | cadmium telluride quantum dots (qds) have received significant attention in biomedical research because of their potential in drug delivery. in this study, the chemotherapeutic agent verbascoside (vb) was immobilized successfully onto cdte qds by covalent bonding between the -oh group of vb and the -cooh group of cdte qds. the amount of vb that could be immobilized depended on the concentration of -cooh groups (succinic acid) on the surface of the cdte qds. apoptotic staining, dna fragmentation and flow cytometry analysis further demonstrated that compared with cdte qds or vb treatment alone, the apoptosis rate increased after the treatment of cdte qds together with vb (vb-qds) in hepg2/adm cells. we observed that vb-qds treatment could clearly activate apoptosis-related caspase 3 expression in hepg2/adm cells. moreover, our in vivo study indicated that the treatment of vb-qds effectively inhibited the human hepatoma hepg2/adm nude mice tumor growth. the increased cell apoptosis rate was closely correlated with the enhanced inhibition of tumor growth in the studied animals. thus, vb-qds may serve as a possible alternative for therapeutic approaches for some cancer treatments. in summary, studies have shown that cancer cells are treated by the presence of vb-qds nanoparticles based on analysis of cell apoptosis. |
| 英文摘要 | cadmium telluride quantum dots (qds) have received significant attention in biomedical research because of their potential in drug delivery. in this study, the chemotherapeutic agent verbascoside (vb) was immobilized successfully onto cdte qds by covalent bonding between the -oh group of vb and the -cooh group of cdte qds. the amount of vb that could be immobilized depended on the concentration of -cooh groups (succinic acid) on the surface of the cdte qds. apoptotic staining, dna fragmentation and flow cytometry analysis further demonstrated that compared with cdte qds or vb treatment alone, the apoptosis rate increased after the treatment of cdte qds together with vb (vb-qds) in hepg2/adm cells. we observed that vb-qds treatment could clearly activate apoptosis-related caspase 3 expression in hepg2/adm cells. moreover, our in vivo study indicated that the treatment of vb-qds effectively inhibited the human hepatoma hepg2/adm nude mice tumor growth. the increased cell apoptosis rate was closely correlated with the enhanced inhibition of tumor growth in the studied animals. thus, vb-qds may serve as a possible alternative for therapeutic approaches for some cancer treatments. in summary, studies have shown that cancer cells are treated by the presence of vb-qds nanoparticles based on analysis of cell apoptosis. |
| WOS标题词 | science & technology ; technology ; physical sciences |
| 类目[WOS] | nanoscience & nanotechnology ; materials science, multidisciplinary ; physics, applied |
| 研究领域[WOS] | science & technology - other topics ; materials science ; physics |
| 关键词[WOS] | daunorubicin induce apoptosis ; fe3o4 nanoparticles ; quantum dots ; in-vivo ; pathway ; cells ; therapy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319747400009 |
| 公开日期 | 2014-05-09 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/3938]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 2.Key Lab Plateau Crop Germplasm Innovat & Utilizat, State Key Lab Breeding Base, Xining 810016, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, State Key Lab Reprod Med, Dept Gynecol Endocrine, Nanjing 210029, Jiangsu, Peoples R China 5.NanJing Med Univ, Sch Basic Med Sci, Dept Cell Biol, Nanjing 210029, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Xiao-Hui,Yue, Hui-Lan,Li, Ping,et al. EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE[J]. nano,2013,8(3). |
| APA | Zhao, Xiao-Hui,Yue, Hui-Lan,Li, Ping,Zeng, Xin,&Zhang, Gen.(2013).EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE.nano,8(3). |
| MLA | Zhao, Xiao-Hui,et al."EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE".nano 8.3(2013). |
入库方式： OAI收割
来源：西北高原生物研究所
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