Analysis of estrogenic compounds in environmental and biological samples by liquid chromatography-tandem mass spectrometry with stable isotope-coded ionization-enhancing reagent
文献类型：期刊论文
| 作者 | Zhang, Shijuan1,3; You, Jinmao1,2; Ning, Shujing2; Song, Cuihua2; Suo, You-Rui1 |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2013-03-08 |
| 卷号 | 1280页码:84-91 |
| 关键词 | Estrogenic compounds Stable isotope labeling LC-MS/MS Matrix effects |
| ISSN号 | 0021-9673 |
| 通讯作者 | you, jm (reprint author), chinese acad sci, northwest inst plateau biol, xining 810001, peoples r china. |
| 中文摘要 | a sensitive and reliable stable isotope labeling technology was developed for the determination of estrogenic compounds in environmental and biological samples based on the derivatization of estrogenic compounds with 10-methyl-acridone-2-sulfonyl chloride (d(0)-masc) and its deuterated counterpart d(3)-masc. the labeling reaction of masc with estrogenic compounds is simple and robust and can be carried out under mild conditions within 5 min. internal standard-based quantification was achieved by this labeling strategy without the need of using expensive internal standard analogy to every analyte of interest. meanwhile, the sensitivity obtained by liquid chromatography-tandem mass spectrometry (lc-ms/ms) was enhanced by 2-3 orders of magnitude compared to the underivatized counterparts. application of the stable isotope labeling technology in relative and absolute quantification of estrogenic compounds in complicated samples indicated that the labeling strategy was effective in overcoming matrix effects. the proposed method was successfully applied to the analysis estrogenic compounds in different environmental and biological samples with high sensitivity and accuracy. (c) 2013 elsevier b.v. all rights reserved. |
| 英文摘要 | a sensitive and reliable stable isotope labeling technology was developed for the determination of estrogenic compounds in environmental and biological samples based on the derivatization of estrogenic compounds with 10-methyl-acridone-2-sulfonyl chloride (d(0)-masc) and its deuterated counterpart d(3)-masc. the labeling reaction of masc with estrogenic compounds is simple and robust and can be carried out under mild conditions within 5 min. internal standard-based quantification was achieved by this labeling strategy without the need of using expensive internal standard analogy to every analyte of interest. meanwhile, the sensitivity obtained by liquid chromatography-tandem mass spectrometry (lc-ms/ms) was enhanced by 2-3 orders of magnitude compared to the underivatized counterparts. application of the stable isotope labeling technology in relative and absolute quantification of estrogenic compounds in complicated samples indicated that the labeling strategy was effective in overcoming matrix effects. the proposed method was successfully applied to the analysis estrogenic compounds in different environmental and biological samples with high sensitivity and accuracy. (c) 2013 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | solid-phase extraction ; endocrine-disrupting compounds ; electrospray-ionization ; gas-chromatography ; lc-ms/ms ; relative quantification ; sewage-sludge ; esi-ms ; derivatization ; water |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000315758700009 |
| 公开日期 | 2014-05-09 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/3954]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 2.Qufu Normal Univ, Key Lab Life Organ Anal Shandong Prov, Qufu, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shijuan,You, Jinmao,Ning, Shujing,et al. Analysis of estrogenic compounds in environmental and biological samples by liquid chromatography-tandem mass spectrometry with stable isotope-coded ionization-enhancing reagent[J]. journal of chromatography a,2013,1280:84-91. |
| APA | Zhang, Shijuan,You, Jinmao,Ning, Shujing,Song, Cuihua,&Suo, You-Rui.(2013).Analysis of estrogenic compounds in environmental and biological samples by liquid chromatography-tandem mass spectrometry with stable isotope-coded ionization-enhancing reagent.journal of chromatography a,1280,84-91. |
| MLA | Zhang, Shijuan,et al."Analysis of estrogenic compounds in environmental and biological samples by liquid chromatography-tandem mass spectrometry with stable isotope-coded ionization-enhancing reagent".journal of chromatography a 1280(2013):84-91. |
入库方式： OAI收割
来源：西北高原生物研究所
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