A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
文献类型：期刊论文
| 作者 | Yue, Wen1,2; Chen, Ziheng1,2; Liu, Haiyang3 ; Yan, Chen3; Chen, Ming1,2; Feng, Du4; Yan, Chaojun; Wu, Hao1,2; Du, Lei1,2; Wang, Yueying1,2
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| 刊名 | CELL RESEARCH
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| 出版日期 | 2014-04-01 |
| 卷号 | 24期号:4页码:482-496 |
| 关键词 | mitochondrial fusion mitofusin1/2 deubiquitinase USP30 15-Oxospiramilactone |
| ISSN号 | 1001-0602 |
| 通讯作者 | Chen, Q (reprint author), Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Lab Apoptosis & Mitochondrial Biol, Beijing 100101, Peoples R China. ; haoxj@mail.kib.ac.cn ; chenq@ioz.ac.cn |
| 英文摘要 | Mitochondrial fusion is a highly coordinated process that mixes and unifies the mitochondrial compartment for normal mitochondrial functions and mitochondrial DNA inheritance. Dysregulated mitochondrial fusion causes mitochondrial fragmentation, abnormal mitochondrial physiology and inheritance, and has been causally linked with a number of neuronal diseases. Here, we identified a diterpenoid derivative 15-oxospiramilactone (S3) that potently induced mitochondrial fusion to restore the mitochondrial network and oxidative respiration in cells that are deficient in either Mfn1 or Mfn2. A mitochondria-localized deubiquitinase USP30 is a target of S3. The inhibition of USP30 by S3 leads to an increase of non-degradative ubiquitination of Mfn1/2, which enhances Mfn1 and Mfn2 activity and promotes mitochondrial fusion. Thus, through the use of an inhibitor of USP30, our study uncovers an unconventional function of non-degradative ubiquitination of Mfns in promoting mitochondrial fusion. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 研究领域[WOS] | Cell Biology |
| 关键词[WOS] | DYNAMIN-RELATED GTPASE ; OUTER-MEMBRANE ; COMPETENT MITOCHONDRIA ; EMBRYONIC-DEVELOPMENT ; MITOFUSIN ; PROTEIN ; UBIQUITIN ; FISSION ; MORPHOLOGY ; MUTATIONS |
| 收录类别 | SCI |
| 资助信息 | Natural Science Foundation of China (NSFC) [91213304, 81130045]; Ministry of Sciences and Technology [2011CB910903, 2010CB912204]; NSFC-joint foundation of Yunnan Province [U1032603] |
| 语种 | 英语 |
| WOS记录号 | WOS:000334400600010 |
| 公开日期 | 2014-05-16 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18040]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Lab Apoptosis & Mitochondrial Biol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources W, Kunming 650204, Yunnan, Peoples R China 4.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China 5.Peking Univ, Peking Tsinghua Ctr Life Sci, Inst Mol Med, Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 6.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Wen,Chen, Ziheng,Liu, Haiyang,et al. A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30[J]. CELL RESEARCH,2014,24(4):482-496. |
| APA | Yue, Wen.,Chen, Ziheng.,Liu, Haiyang.,Yan, Chen.,Chen, Ming.,...&Chen, Quan.(2014).A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30.CELL RESEARCH,24(4),482-496. |
| MLA | Yue, Wen,et al."A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30".CELL RESEARCH 24.4(2014):482-496. |
入库方式： OAI收割
来源：昆明植物研究所
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