Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells
文献类型：期刊论文
| 作者 | Zhang, Jingjie1; Gao, Guangxun1,2; Chen, Liang1; Li, Jingxia1; Deng, Xu3 ; Zhao, Qin-shi3; Huang, Chuanshu1
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| 刊名 | ONCOTARGET
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:3页码:841-852 |
| 关键词 | Cheliensisin A Apoptosis colon cancer p53 chemotherapeutic agent |
| ISSN号 | 1949-2553 |
| 通讯作者 | Huang, CS (reprint author), NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA. ; qinshizhao@mail.kib.ac.cn ; chuanshu.huang@nyumc.org |
| 英文摘要 | Cheliensisine A (Chel A) as a novel styryl-lactone isolated from Goniothalamus cheliensis Hu has been indicated to be a chemotherapeutic agent in Leukemia HL-60 cells. However, its potential for cancer treatment and the underlying mechanisms are not deeply investigated to the best of our knowledge. Current studies showed that Chel A could trigger p53-mediated apoptosis, accompanied with dramatically inhibition of anchorage-independent growth of human colon cancer HCT116 cells. Further studies found that Chel A treatment resulted in p53 protein stabilization and accumulation via the induction of its phosphorylation at Ser20 and Ser15. Moreover, Chel A-induced p53 protein accumulation and activation required ATR/Chk2 axis, which is distinct from the mechanism that we have most recently identified the Chk1/p53-dependent apoptotic response by Chel A in normal mouse epidermal Cl41 cells. In addition, our results demonstrated that hydrogen peroxide generation induced by Chel A acted as a precursor for all these signaling events and downstream biological effects. Taken together, we have identified the Chel A as a new therapeutic agent, which highlights its potential for cancer therapeutic effect. |
| 学科主题 | Oncology ; Cell Biology |
| 类目[WOS] | Oncology ; Cell Biology |
| 研究领域[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | DNA-DAMAGE ; INDUCED PHOSPHORYLATION ; DOWN-REGULATION ; APOPTOSIS ; EXPRESSION ; INDUCTION ; PATHWAY ; TRANSFORMATION ; HYPEROXIA ; MDM2 |
| 收录类别 | SCI |
| 资助信息 | NIH/NCI [RO1 CA177665, CA165980, RO1 CA112557]; NIH/NIEHS [ES000260]; [NSFC81229002]; [NSF90813004] |
| 语种 | 英语 |
| WOS记录号 | WOS:000332701300023 |
| 公开日期 | 2014-05-16 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18052]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA 2.Fourth Mil Med Univ, Xijing Hosp, Dept Hematol, Xian 710032, Shaanxi, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jingjie,Gao, Guangxun,Chen, Liang,et al. Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells[J]. ONCOTARGET,2014,5(3):841-852. |
| APA | Zhang, Jingjie.,Gao, Guangxun.,Chen, Liang.,Li, Jingxia.,Deng, Xu.,...&Huang, Chuanshu.(2014).Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells.ONCOTARGET,5(3),841-852. |
| MLA | Zhang, Jingjie,et al."Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells".ONCOTARGET 5.3(2014):841-852. |
入库方式： OAI收割
来源：昆明植物研究所
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