Cytotoxic Amides and Quinolones from Clausena lansium
文献类型：期刊论文
| 作者 | Song, Wei-Wu1,2; Zeng, Guang-Zhi1; Peng, Wen-Wen1; Chen, Ke-Xian1,2; Tan, Ning-Hua1 |
| 刊名 | HELVETICA CHIMICA ACTA
 |
| 出版日期 | 2014-02-01 |
| 卷号 | 97期号:2页码:298-305 |
| 关键词 | Quinolones Clausena lansium Cytotoxic activity Claulansamides A and B Amides |
| ISSN号 | 0018-019X |
| 英文摘要 | Two new amides, claulansamides A and B (1 and 2, resp.), together with five known amides, 3-7 and six known quinolones, 8-13, were isolated from the stems and roots of Clausena lansium. Their structures were elucidated on the basis of extensive spectroscopic methods. Their absolute configurations were determined by single-crystal X-ray diffraction technique, CD, and optical rotation. HPLC Chiral separation of 1 afforded two enantiomers, (+)- and (-)-claulansamide A, respectively. Compounds 9, 12, and 13 were isolated from the genus Clausena for the first time. All compounds were evaluated for their cytotoxic activities against A549, BGC-823, and HeLa cancer cell lines. However, only 9 showed cytotoxic activity against A549 cell line with an IC50 value of 46.3 mu M, and 11 against BGC-823 and HeLa cell lines with the IC50 values of 55.0 and 14.7 mu M, respectively. |
| 学科主题 | Chemistry, Multidisciplinary |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CHEMICAL-CONSTITUENTS ; CARBAZOLE ALKALOIDS ; COUMARIN ; ANISATA ; SEEDS ; STEMS |
| 收录类别 | SCI ; IC |
| 资助信息 | National New Drug Innovation Major Project of China [2011ZX09307-002-02]; National Natural Science Foundation of China [U1032602, 91013002, 30725048]; National Basic Research Program of China [2009CB522300]; Fund of Chinese Academy of Sciences (Hundred Talents Program); Natural Science Foundation of Yunnan Province [2012GA003] |
| 语种 | 英语 |
| WOS记录号 | WOS:000331959500012 |
| 公开日期 | 2014-05-16 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18055]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Wei-Wu,Zeng, Guang-Zhi,Peng, Wen-Wen,et al. Cytotoxic Amides and Quinolones from Clausena lansium[J]. HELVETICA CHIMICA ACTA,2014,97(2):298-305. |
| APA | Song, Wei-Wu,Zeng, Guang-Zhi,Peng, Wen-Wen,Chen, Ke-Xian,&Tan, Ning-Hua.(2014).Cytotoxic Amides and Quinolones from Clausena lansium.HELVETICA CHIMICA ACTA,97(2),298-305. |
| MLA | Song, Wei-Wu,et al."Cytotoxic Amides and Quinolones from Clausena lansium".HELVETICA CHIMICA ACTA 97.2(2014):298-305. |
入库方式： OAI收割
来源：昆明植物研究所
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