A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles
文献类型：期刊论文
| 作者 | Wang JD ; Chen WW; Sun JS; Liu C(刘超); Yin QF; Zhang L; Xianyu YL; Shi XH(施兴华); Hu GQ(胡国庆); Jiang XY
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| 刊名 | LAB ON A CHIP
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| 出版日期 | 2014 |
| 卷号 | 14期号:10页码:1673-1677 |
| 通讯作者邮箱 | sunjs@nanoctr.cn; guoqing.hu@imech.ac.cn; xingyujiang@nanoctr.cn |
| ISSN号 | 1473-0197 |
| 产权排序 | [Wang, Jidong; Chen, Wenwen; Sun, Jiashu; Zhang, Lu; Xianyu, Yunlei; Jiang, Xingyu] Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China; [Wang, Jidong; Chen, Wenwen; Sun, Jiashu; Zhang, Lu; Xianyu, Yunlei; Jiang, Xingyu] Natl Ctr NanoSci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Liu, Chao; Yin, Qifang; Shi, Xinghua; Hu, Guoqing] Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China |
| 通讯作者 | Sun, JS (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China. |
| 合作状况 | 国内 |
| 中文摘要 | This report describes a straightforward but robust tubing method for connecting polydimethylsiloxane (PDMS) microfluidic devices to external equipment. The interconnection is irreversible and can sustain a pressure of up to 4.5 MPa that is characterized experimentally and theoretically. To demonstrate applications of this high-pressure tubing technique, we fabricate a semicircular microfluidic channel to implement a high-throughput, size-controlled synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ranging from 55 to 135 nm in diameter. This microfluidic device allows for a total flow rate of 410 mL h(-1), resulting in enhanced convective mixing which can be utilized to precipitate small size nanoparticles with a good dispersion. We expect that this tubing technique would be widely used in microfluidic chips for nanoparticle synthesis, cell manipulation, and potentially nanofluidic applications. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics |
| 分类号 | 一类 |
| 收录类别 | SCI |
| 资助信息 | X. J. and J. S. acknowledge financial support from MOST (2011CB933201, 2012AA030308, 2012AA022703 and 2013AA032204), NSFC (51105086, 91213305, 21025520, and 51073045), and the Chinese Academy of Sciences and Beijing Municipal Science & Technology Commission (Z131100002713024). |
| 原文出处 | http://dx.doi.org/10.1039/c4lc00080c |
| 语种 | 英语 |
| WOS记录号 | WOS:000334866500004 |
| 公开日期 | 2014-06-05 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/48835]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang JD,Chen WW,Sun JS,et al. A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles[J]. LAB ON A CHIP,2014,14(10):1673-1677. |
| APA | Wang JD.,Chen WW.,Sun JS.,Liu C.,Yin QF.,...&Jiang XY.(2014).A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles.LAB ON A CHIP,14(10),1673-1677. |
| MLA | Wang JD,et al."A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles".LAB ON A CHIP 14.10(2014):1673-1677. |
入库方式： OAI收割
来源：力学研究所
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