Enhanced cytotoxicity of pentachlorophenol by perfluorooctane sulfonate or perfluorooctanoic acid in HepG2 cells
文献类型：期刊论文
| 作者 | Shan, Guoqiang ; Ye, Minqiang ; Zhu, Benzhan ; Zhu, Lingyan |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2013 |
| 卷号 | 93期号:9页码:2101-2107 |
| 通讯作者 | Zhu, LY |
| 中文摘要 | Chlorinated phenols and perfluoroalkyl acids (PFAAs) are two kinds of pollutants which are widely present in the environment. Considering liver is the primary toxic target organ for these two groups of chemicals, it is interesting to evaluate the possible joint effects of them on liver. In this work, the combined toxicity of pentachlorophenol (PCP) and perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA) were investigated using HepG2 cells. The results indicated that PFOS and PFOA could strengthen PCP's hepatotoxicity. Further studies showed that rather than intensify the oxidative stress or promote the biotransformation of PCP, PFOS (or PFOA) might lead to strengthening of the oxidative phosphorylation uncoupling of PCP. By measuring the intracellular PCP concentration and the cell membrane properties, it was suggested that PFOS and PFOA could disrupt the plasma membrane and increase the membrane permeability. Thus, more cellular accessibility of PCP was induced when they were co-exposed to PCP and PFOS (or PFOA), leading to increased cytotoxicity. Further research is warranted to better understand the combined toxicity of PFAAs and other environmental pollutants. (C) 2013 Published by Elsevier Ltd. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000327109300058 |
| 公开日期 | 2014-06-06 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/7456]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Shan, Guoqiang,Ye, Minqiang,Zhu, Benzhan,et al. Enhanced cytotoxicity of pentachlorophenol by perfluorooctane sulfonate or perfluorooctanoic acid in HepG2 cells[J]. CHEMOSPHERE,2013,93(9):2101-2107. |
| APA | Shan, Guoqiang,Ye, Minqiang,Zhu, Benzhan,&Zhu, Lingyan.(2013).Enhanced cytotoxicity of pentachlorophenol by perfluorooctane sulfonate or perfluorooctanoic acid in HepG2 cells.CHEMOSPHERE,93(9),2101-2107. |
| MLA | Shan, Guoqiang,et al."Enhanced cytotoxicity of pentachlorophenol by perfluorooctane sulfonate or perfluorooctanoic acid in HepG2 cells".CHEMOSPHERE 93.9(2013):2101-2107. |
入库方式： OAI收割
来源：生态环境研究中心
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