Proteomic Analysis of Human Keratinocyte Response to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure
文献类型：期刊论文
| 作者 | Hu, Qin ; Rice, Robert H. ; Qin, Qin ; Phinney, Brett S. ; Eigenheer, Richard A. ; Bao, Wenjun ; Zhao, Bin |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 12期号:11页码:5340-5347 |
| 通讯作者 | Zhao, B |
| 中文摘要 | Chronic exposure to 2,3,7,8-tetrachlorodibeno-p-dioxin (TCDD) and related polyhalogenated organic pollutants occurs as a consequence of modern life. Exploring the cellular basis for their action is anticipated to help understand the risk they pose and improve the foundation for their regulation. A basis for the striking change in human keratinocyte colony morphology due to TCDD exposure has been investigated by shotgun proteomics. Concentrating on changes in protein levels among three cell strains has revealed 7,2 significant decreases in the differentiation markers filaggrin, keratin 1, and keratin 10. EGF treatment in concert with TCDD enhanced the changes in these markers and several other proteins while reducing the levels of certain other proteins. The only protein stimulated by TCDD in all three strains and reversed by EGF in them was vimentin, not previously observed to be in the aryl hydrocarbon receptor response domain. Although TCDD is often proposed to enhance keratinocyte differentiation, proteomic analysis reveals it uncouples the differentiation program and suggests that reduced levels of differentiation marker proteins contribute to the observed excessive stratification it induces. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000326615000055 |
| 公开日期 | 2014-06-06 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/7459]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Hu, Qin,Rice, Robert H.,Qin, Qin,et al. Proteomic Analysis of Human Keratinocyte Response to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure[J]. JOURNAL OF PROTEOME RESEARCH,2013,12(11):5340-5347. |
| APA | Hu, Qin.,Rice, Robert H..,Qin, Qin.,Phinney, Brett S..,Eigenheer, Richard A..,...&Zhao, Bin.(2013).Proteomic Analysis of Human Keratinocyte Response to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure.JOURNAL OF PROTEOME RESEARCH,12(11),5340-5347. |
| MLA | Hu, Qin,et al."Proteomic Analysis of Human Keratinocyte Response to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure".JOURNAL OF PROTEOME RESEARCH 12.11(2013):5340-5347. |
入库方式： OAI收割
来源：生态环境研究中心
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