Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells
文献类型：期刊论文
| 作者 | Li, Zhuona ; Yin, Nuoya ; Liu, Qian ; Wang, Chang ; Wang, Thanh ; Wang, Yichen ; Qu, Guangbo ; Liu, Jiyan ; Cai, Yaqi ; Zhou, Qunfang ; Jiang, Guibin |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2013 |
| 卷号 | 90期号:3页码:1227-1235 |
| 通讯作者 | Zhou, QF |
| 中文摘要 | 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-(gamma)-2-benzopyran (HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (AHTN) are widely used in personal care products. Previous studies showed that HHCB and AHTN can be found in various environmental matrices and have potential endocrine disrupting effects. However, the effects on adrenocortical function of HHCB and AHTN are not fully understood. This study evaluated the influences of HHCB and AHTN on seven steroid hormones (progesterone, aldosterone, cortisol, 17 alpha-OH-progesterone, androstenedione, 17 beta-estradiol, and testosterone) and 10 genes involved in steroidogenic pathways (HMGR, StAR, CYP11A1, 3 beta HSD2, CYP17, CYP21, CYP11B1, CYP11B2, 17 beta HSD, and CYP19) using the H295R cell line in the absence and presence of 8-Br-cAMP. MC2R transcription on the cell membrane was also examined to further investigate the effects of HHCB and AHTN on adrenal steroidogenesis. The results demonstrated that HHCB and AHTN could inhibit progesterone and cortisol production mainly by the suppression of 3 beta HSD2 and CYP21. Meanwhile, high concentrations of AHTN can affect the sensitivity of H295R cells to ACTH by disrupting MR transcription. Overall, the results indicate that high concentrations of HHCB and AHTN can affect steroidogenesis in vitro using the H295R cell line. (C) 2012 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000312978700044 |
| 公开日期 | 2014-06-06 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/7553]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Zhuona,Yin, Nuoya,Liu, Qian,et al. Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells[J]. CHEMOSPHERE,2013,90(3):1227-1235. |
| APA | Li, Zhuona.,Yin, Nuoya.,Liu, Qian.,Wang, Chang.,Wang, Thanh.,...&Jiang, Guibin.(2013).Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells.CHEMOSPHERE,90(3),1227-1235. |
| MLA | Li, Zhuona,et al."Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells".CHEMOSPHERE 90.3(2013):1227-1235. |
入库方式： OAI收割
来源：生态环境研究中心
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