Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility
文献类型：期刊论文
| 作者 | Li, Rong ; Wang, Hengdong ; Wang, Wenfeng ; Ye, Yin |
| 刊名 | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
 |
| 出版日期 | 2013 |
| 卷号 | 24期号:1页码:CONCATENATE(Sheet1!I162,-Sheet1!J162) |
| ISSN号 | 0920-5063 |
| 英文摘要 | A polypropylene non-woven fabric (PPNWF) was exposed to oxygen plasma to produce peroxides on its surface. These peroxides were used to initiate graft polymerization of acrylic acid (AA) on the surface of PPNWF. Direct heparinization was accomplished via a reaction between heparin and PP-PAA (AA grafted PPNWF) which was activated by EDC (N-ethyl-N'-[3-(dimethylamino)propyl] carbodiimide). Indirect heparinized PPNWF was prepared by grafting poly(ethylene oxide) (PEO) on a PP-PAA surface to form PP-PAA-PEO, followed by reaction with heparin which was activated by EDC before use. The surface-modified PPNWFs were characterized by attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectroscopy, electron spectroscopy for chemical analysis (ESCA) and contact angle goniometry. It was found that hydrophilicity was greatly improved, as indicated by the decrease of the water contact angle from 142 to 33 degrees. In vitro blood compatibility evaluation of modified PPNWFs, including hemolysis rate, platelet adhesion, plasma protein adsorption and activated partial thromboplastin time (APTT) was investigated. The results suggested that both heparinized PPNWFs showed lower hemolysis rates and better platelet anti-adhesion than non-heparinized controls. Furthermore, PPNWF obtained via indirect immobilization of heparin showed better hydrophilicity and blood compatibility than direct heparinization of PPNWF. (C) Koninklijke Brill NV, Leiden, 2012 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000311543500002 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13625]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Li, Rong,Wang, Hengdong,Wang, Wenfeng,et al. Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2013,24(1):CONCATENATE(Sheet1!I162,-Sheet1!J162). |
| APA | Li, Rong,Wang, Hengdong,Wang, Wenfeng,&Ye, Yin.(2013).Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,24(1),CONCATENATE(Sheet1!I162,-Sheet1!J162). |
| MLA | Li, Rong,et al."Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 24.1(2013):CONCATENATE(Sheet1!I162,-Sheet1!J162). |
入库方式： OAI收割
来源：上海应用物理研究所
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