A silicon-based electrochemical sensor for highly sensitive, specific, label-free and real-time DNA detection
文献类型：期刊论文
| 作者 | Guo, YY ; Su, S ; Wei, XP ; Zhong, YL ; Su, YY ; Huang, Q（黄庆） ; Fan, CH（樊春海） ; He, Y |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 24期号:44 |
| ISSN号 | 0957-4484; 1361-6528 |
| 英文摘要 | We herein present a new kind of silicon-based electrochemical sensor using a gold nanoparticles-decorated silicon wafer (AuNPs@Si) as a high-performance electrode, which is facilely prepared via in situ AuNPs growth on a silicon wafer. Particularly significantly, the resultant electrochemical sensor is efficacious for label-free DNA detection with high sensitivity due to the unique merits of the prepared silicon- based electrode. Typically, DNA at remarkably low concentrations (1-10 fM) could be readily detected without requiring additional signal-amplification procedures, which is better than or comparable to the lowest DNA concentration ever detected via well-studied signal-amplification-assisted electrochemical sensors. Moreover, the silicon-based sensor features high specificity, allowing unambiguous discrimination of single-based mismatches. We further show that real-time DNA assembly is readily monitored via recording the intensity changes of current signals due to the robust thermal stability of the silicon-based electrode. The unprecedented advantages of the silicon-based electrochemical sensor would offer new opportunities for myriad sensing applications. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000326015600015 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13660]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Guo, YY,Su, S,Wei, XP,et al. A silicon-based electrochemical sensor for highly sensitive, specific, label-free and real-time DNA detection[J]. NANOTECHNOLOGY,2013,24(44). |
| APA | Guo, YY.,Su, S.,Wei, XP.,Zhong, YL.,Su, YY.,...&He, Y.(2013).A silicon-based electrochemical sensor for highly sensitive, specific, label-free and real-time DNA detection.NANOTECHNOLOGY,24(44). |
| MLA | Guo, YY,et al."A silicon-based electrochemical sensor for highly sensitive, specific, label-free and real-time DNA detection".NANOTECHNOLOGY 24.44(2013). |
入库方式： OAI收割
来源：上海应用物理研究所
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