Aggregated Gas Molecules: Toxic to Protein?
文献类型：期刊论文
| 作者 | Zhang, Meng ; Zuo, Guanghong ; Chen, Jixiu ; Gao, Yi ; Fang, Haiping(方海平） |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2013 |
| 卷号 | 3 |
| ISSN号 | 2045-2322 |
| 英文摘要 | The biological toxicity of high levels of breathing gases has been known for centuries, but the mechanism remains elusive. Earlier work mainly focused on the influences of dispersed gas molecules dissolved in water on biomolecules. However, recent studies confirmed the existence of aggregated gas molecules at the water-solid interface. In this paper, we have investigated the binding preference of aggregated gas molecules on proteins with molecular dynamics simulations, using nitrogen (N-2) gas and the Src-homology 3 (SH3) domain as the model system. Aggregated N-2 molecules were strongly bound by the active sites of the SH3 domain, which could impair the activity of the protein. In contrast, dispersed N2 molecules did not specifically interact with the SH3 domain. These observations extend our understanding of the possible toxicity of aggregates of gas molecules in the function of proteins. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317576800001 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13665]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhang, Meng,Zuo, Guanghong,Chen, Jixiu,et al. Aggregated Gas Molecules: Toxic to Protein?[J]. SCIENTIFIC REPORTS,2013,3. |
| APA | Zhang, Meng,Zuo, Guanghong,Chen, Jixiu,Gao, Yi,&Fang, Haiping.(2013).Aggregated Gas Molecules: Toxic to Protein?.SCIENTIFIC REPORTS,3. |
| MLA | Zhang, Meng,et al."Aggregated Gas Molecules: Toxic to Protein?".SCIENTIFIC REPORTS 3(2013). |
入库方式： OAI收割
来源：上海应用物理研究所
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