Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice
文献类型：期刊论文
| 作者 | Li, Bo ; Yang, Jianzhong（杨建忠） ; Huang, Qing（黄庆） ; Zhang, Yi ; Peng, Cheng（彭程） ; Zhang, Yujie ; He, Yao ; Shi, Jiye ; Li, Wenxin（李文新） ; Hu, Jun（胡钧） ; Fan, Chunhai（樊春海） |
| 刊名 | NPG ASIA MATERIALS
 |
| 出版日期 | 2013 |
| 卷号 | 5 |
| ISSN号 | 1884-4049 |
| 英文摘要 | Graphene and its derivatives (for example, nanoscale graphene oxide (NGO)) have emerged as extremely attractive nanomaterials for a wide range of applications, including diagnostics and therapeutics. In this work, we present a systematic study on the in vivo distribution and pulmonary toxicity of NGO for up to 3 months after exposure. Radioisotope tracing and morphological observation demonstrated that intratracheally instilled NGO was mainly retained in the lung. NGO could result in acute lung injury (ALI) and chronic pulmonary fibrosis. Such NGO-induced ALI was related to oxidative stress and could effectively be relieved with dexamethasone treatment. In addition, we found that the biodistribution of I-125-NGO varied greatly from that of I-125 ions, hence it is possible that nanoparticulates could deliver radioactive isotopes deep into the lung, which might settle in numerous 'hot spots' that could result in mutations and cancers, raising environmental concerns about the large-scale production of graphene oxide. NPG Asia Materials (2013) 5, e44; doi:10.1038/am.2013.7; published online 5 April 2013 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318147400001 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13681]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Li, Bo,Yang, Jianzhong,Huang, Qing,et al. Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice[J]. NPG ASIA MATERIALS,2013,5. |
| APA | Li, Bo.,Yang, Jianzhong.,Huang, Qing.,Zhang, Yi.,Peng, Cheng.,...&Fan, Chunhai.(2013).Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice.NPG ASIA MATERIALS,5. |
| MLA | Li, Bo,et al."Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice".NPG ASIA MATERIALS 5(2013). |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。