Conjugation of Dexamethasone to C60 for the Design of an Anti-Inflammatory Nanomedicine with Reduced Cellular Apoptosis
文献类型：期刊论文
| 作者 | Zhang, Yi（张益） ; Wang, Lu ; Sun, Yanhong（孙艳红） ; Zhu, Ying（诸颖） ; Zhong, Zengtao ; Shi, Jiye ; Fan, Chunhai（樊春海） ; Huang, Qing（黄庆） |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:11页码:CONCATENATE(Sheet1!I64,-Sheet1!J64) |
| ISSN号 | 1944-8244 |
| 英文摘要 | Dexamethasone (DEX) is a well-known anti-inflammatory drug, whose widespread clinical use is nevertheless restricted by its serious side effects. By conjugation of DEX with C-60, we found that this nanomedicine retained the anti-inflammatory activity of DEX while reducing side effects in the animal model. In mouse thymocytes, the CCK-8 assay showed that the cytotoxicity of DEX-C-60 was significantly lower than that of free DEX. Flow cytometric studies revealed that incubation with DEX-C-60 induced much less apoptotic thymocytes. Interestingly, such reduced cytotoxicity and apoptosis were not observed when equal moles of free C-60 and free DEX were coincubated with thymocytes suggesting that the conjugation alters the signal pathway of DEX Indeed, found that the binding of DEX-C-60 and a glucocorticoid receptor (GR) was partially blocked in the thymocytes, which resulted in down-regulation of several apoptosis-related genes. These findings help understand the mechanism of beneficial effects of this new nanomedicine, DEX-C-60, and promote its clinical applications. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320484000107 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13696]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhang, Yi,Wang, Lu,Sun, Yanhong,et al. Conjugation of Dexamethasone to C60 for the Design of an Anti-Inflammatory Nanomedicine with Reduced Cellular Apoptosis[J]. ACS APPLIED MATERIALS & INTERFACES,2013,5(11):CONCATENATE(Sheet1!I64,-Sheet1!J64). |
| APA | Zhang, Yi.,Wang, Lu.,Sun, Yanhong.,Zhu, Ying.,Zhong, Zengtao.,...&Huang, Qing.(2013).Conjugation of Dexamethasone to C60 for the Design of an Anti-Inflammatory Nanomedicine with Reduced Cellular Apoptosis.ACS APPLIED MATERIALS & INTERFACES,5(11),CONCATENATE(Sheet1!I64,-Sheet1!J64). |
| MLA | Zhang, Yi,et al."Conjugation of Dexamethasone to C60 for the Design of an Anti-Inflammatory Nanomedicine with Reduced Cellular Apoptosis".ACS APPLIED MATERIALS & INTERFACES 5.11(2013):CONCATENATE(Sheet1!I64,-Sheet1!J64). |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。