Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells
文献类型：期刊论文
| 作者 | Wang, Lu ; Xu, Xiaoping ; Zhang, Yi（张益） ; Zhang, Yuanqing ; Zhu, Ying（诸颖） ; Shi, Jiye ; Sun, Yanhong（孙艳红） ; Huang, Qing（黄庆） |
| 刊名 | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
 |
| 出版日期 | 2013 |
| 卷号 | 24期号:9页码:CONCATENATE(Sheet1!I112,-Sheet1!J112) |
| ISSN号 | 0957-4530 |
| 英文摘要 | Curcumin has anti-proliferative and pro-apototic properties against a variety of cancer cells in vitro. Unfortunately, the water-insolubility and instability leads to its low bioavailability in vivo tests. Here, we report a general approach to using poly(amidoamine) dendrimer with acetyl terminal groups to encapsulate curcumin(G(5)-Ac/Cur) for drug delivery to cancer cells. The solubility, release kinetics, anticancer activity, and apoptotic-related protein expression (Bax and Bcl-2) were investigated in detail. Comparing with curcumin, the water-solubility value of G(5)-Ac/Cur increased 200-fold, and the release of curcumin from the complexes was in a sustained manner. G(5)-Ac/Cur showed higher anti-proliferative activity against A549 cell lines and had the better effect on the generation of intracellular reactive oxygen species, the mitochondrial membrane potential and cell apoptosis. Furthermore, the ratio of Bax/Bcl-2 was higher in samples treated with G(5)-Ac/Cur. The results indicated that the G(5)-Ac drug delivery system could improve the solubility and anti-cancer effect of curcumin. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323289600006 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13739]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wang, Lu,Xu, Xiaoping,Zhang, Yi,et al. Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2013,24(9):CONCATENATE(Sheet1!I112,-Sheet1!J112). |
| APA | Wang, Lu.,Xu, Xiaoping.,Zhang, Yi.,Zhang, Yuanqing.,Zhu, Ying.,...&Huang, Qing.(2013).Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,24(9),CONCATENATE(Sheet1!I112,-Sheet1!J112). |
| MLA | Wang, Lu,et al."Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 24.9(2013):CONCATENATE(Sheet1!I112,-Sheet1!J112). |
入库方式： OAI收割
来源：上海应用物理研究所
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