Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides
文献类型：期刊论文
| 作者 | Kang, Seung-gu ; Tien Huynh ; Xia, Zhen ; Zhang, Yi（张益） ; Fang, Haiping（方海平） ; Wei, Guanghong ; Zhou, Ruhong |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2013 |
| 卷号 | 135期号:8页码:CONCATENATE(Sheet1!I155,-Sheet1!J155) |
| ISSN号 | 0002-7863 |
| 英文摘要 | The molecular mechanism of epitaxial fibril formation has been investigated for GAV-9 (NH3+-VGGAV-VAGV-CONH2), an amyloid-like peptide extracted from a consensus sequence of amyloidogenic proteins, which assembles with very different morphologies, "upright" on mica and "flat" on the highly oriented pyrolytic graphite (HOPG). Our all-atom molecular dynamics simulations reveal that the strong electrostatic interaction induces the "upright" conformation on mica, whereas the hydrophobic interaction favors the "flat" conformation on HOPG. We also show that the epitaxial pattern on mica is ensured by the lattice matching between the anisotropic binding sites of the basal substrate and the molecular dimension of GAV-9, accompanied with a long-range order of well-defined beta-strands. Furthermore, the binding free energy surfaces indicate that the longitudinal assembly growth is predominantly driven by the hydrophobic interaction along the longer crystallographic unit cell direction of mica. These findings provide a molecular basis for the surface-assisted molecular assembly, which might also be useful for the design of de novo nanodevices. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000315618900048 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13772]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Kang, Seung-gu,Tien Huynh,Xia, Zhen,et al. Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2013,135(8):CONCATENATE(Sheet1!I155,-Sheet1!J155). |
| APA | Kang, Seung-gu.,Tien Huynh.,Xia, Zhen.,Zhang, Yi.,Fang, Haiping.,...&Zhou, Ruhong.(2013).Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,135(8),CONCATENATE(Sheet1!I155,-Sheet1!J155). |
| MLA | Kang, Seung-gu,et al."Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135.8(2013):CONCATENATE(Sheet1!I155,-Sheet1!J155). |
入库方式： OAI收割
来源：上海应用物理研究所
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