In vivo behavior of near infrared-emitting quantum dots
文献类型：期刊论文
| 作者 | Lu, Yimei ; Su, Yuanyuan ; Zhou, Yanfeng ; Wang, Jie ; Peng, Fei ; Zhong, Yiling ; Huang, Qing ; Fan, Chunhai ; He, Yao |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:17页码:CONCATENATE(Sheet1!I166,-Sheet1!J166) |
| ISSN号 | 0142-9612 |
| 英文摘要 | Near-infrared (NIR, 700-900 nm) fluorescent nanomaterials-based probes have shown major impacts on high-resolution and high-sensitivity bioimaging applications. Typically, NIR-emitting quantum dots (QDs) are highly promising as NIR bioprobes due to their unique optical properties. However, NIR-emitting QDs-related in vivo behavior remains unknown at present, severely limiting their wide-ranging bioapplications. Herein, we investigate short- and long-term in vivo biodistribution, pharmacokinetics, and toxicity of the NIR-emitting QDs. Particularly, we reveal that the NIR-emitting QDs are initially accumulated in liver, spleen, and lung for short-time (0.5-4 h) post-injection, and then increasingly absorbed by kidney during long-time (4-94 days) blood circulation. Obviously time-dependent biodistribution is observed: with time continues, most of NIR-emitting QDs are finally accumulated in liver and kidney; comparatively, less NIR-emitting QDs are observed in spleen, lung, and bone marrow. Furthermore, histological and biochemical analyses, and body weight measurements demonstrate that there is no overt toxicity of NIR-emitting QDs in mice even at long-time (94 days) exposure time. Our studies provide invaluable information for the design and development of NIR-emitting QDs-based nanoprobes for biological and biomedical applications. (C) 2013 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317700400012 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13779]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Lu, Yimei,Su, Yuanyuan,Zhou, Yanfeng,et al. In vivo behavior of near infrared-emitting quantum dots[J]. BIOMATERIALS,2013,34(17):CONCATENATE(Sheet1!I166,-Sheet1!J166). |
| APA | Lu, Yimei.,Su, Yuanyuan.,Zhou, Yanfeng.,Wang, Jie.,Peng, Fei.,...&He, Yao.(2013).In vivo behavior of near infrared-emitting quantum dots.BIOMATERIALS,34(17),CONCATENATE(Sheet1!I166,-Sheet1!J166). |
| MLA | Lu, Yimei,et al."In vivo behavior of near infrared-emitting quantum dots".BIOMATERIALS 34.17(2013):CONCATENATE(Sheet1!I166,-Sheet1!J166). |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。