Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level
文献类型：期刊论文
| 作者 | Zuo, Guanghong ; Kang, Seung-gu ; Xiu, Peng ; Zhao, Yuliang ; Zhou, Ruhong |
| 刊名 | SMALL
 |
| 出版日期 | 2013 |
| 卷号 | 9期号:41892页码:CONCATENATE(Sheet1!I173,-Sheet1!J173) |
| ISSN号 | 1613-6810 |
| 英文摘要 | The widespread application of nanomaterials has spurred an interest in the study of interactions between nanoparticles and proteins due to the biosafety concerns of these nanomaterials. In this review, a summary is presented of some of the recent studies on this important subject, especially on the interactions of proteins with carbon nanotubes (CNTs) and metallofullerenols. Two potential molecular mechanisms have been proposed for CNTs' inhibition of protein functions. The driving forces of CNTs' adsorption onto proteins are found to be mainly hydrophobic interactions and the so-called stacking between CNTs' carbon rings and proteins' aromatic residues. However, there is also recent evidence showing that endohedral metallofullerenol Gd@C82(OH)22 can be used to inhibit tumor growth, thus acting as a potential nanomedicine. These recent findings have provided a better understanding of nanotoxicity at the molecular level and also suggested therapeutic potential by using nanoparticles' cytotoxicity against cancer cells. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319076000011 |
| 公开日期 | 2014-06-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13786]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zuo, Guanghong,Kang, Seung-gu,Xiu, Peng,et al. Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level[J]. SMALL,2013,9(41892):CONCATENATE(Sheet1!I173,-Sheet1!J173). |
| APA | Zuo, Guanghong,Kang, Seung-gu,Xiu, Peng,Zhao, Yuliang,&Zhou, Ruhong.(2013).Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level.SMALL,9(41892),CONCATENATE(Sheet1!I173,-Sheet1!J173). |
| MLA | Zuo, Guanghong,et al."Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level".SMALL 9.41892(2013):CONCATENATE(Sheet1!I173,-Sheet1!J173). |
入库方式： OAI收割
来源：上海应用物理研究所
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